Super-Microsurgery for vascularized ovarian transplantation:Collaboration: Super-Microsurgery ∗ Small organ transplantation
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概要
- 論文の詳細を見る
Chemotherapy and radiotherapy are essential in the treatment of cancers in children and youngadults; while, these therapies often result in testicular failure or reduced ovarian function. So far, thepriority is exclusively on the treatment of cancer, and these side effects have been under recognized. However, advances in the studies of ovarian cryopreservation are expected to correct the imbalance between the treatment effects and adverse reactions. Particularly for young women with cancer, ovarian cryopreservation before initiation of cancer treatment may give hope for the preservation of fertility. One of the problems in the study of cryopreservation techniques is that use of cryopreserved ovary yields only a very low rate of fertilization. We hypothesized that this is caused by instable blood flow during organ transplantation, so we conducted an experiment in a rat ovarian transplantation model, focusing on vascular anastomosis and cryopreservation. This study is based on the technique of vascular anastomosis, which we call "Super-Microsurgery". First, we examined the feasibility of the technique for ovarian transplantation. We removed vascularized ovaries from recipient rats and anastomosed the vessels of the ovaries to the subcutaneous vessels of donor recipient nude mice. A histological analysis of the group undergoing anastomosis and the group not undergoing anastomosis revealed that ovarian follicles and ovarian granulosa cells were better preserved in the group undergoing anastomosis, indicating the importance of vascular anastomosis in ovarian transplantation.
- 日本学術連携医学会の論文
著者
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Noguchi Shuhei
Department of Plastic Surgery and Reconstructive Surgery, The University of Tokyo
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Nakagawa Takashi
Department Of Biological Science And Technology Faculty Of Engineering The University Of Tokushima
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Mihara Makoto
Department of plastic and reconstructive surgery, The University of Tokyo Hospital.
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Ong Wei
Department of Plastic Surgery, National University Hospital
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