Janus Kinase 2/Signal Transducers and Activators of Transcription Signal Inhibition Regulates Protective Effects of Probucol on Mesangial Cells Treated with High Glucose
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概要
- 論文の詳細を見る
Probucol is a cholesterol-lowering drug with an anti-proliferative effect. Excessive growth of glomerular mesangial cells and overexpression of transforming growth factor-β1 (TGF-β1) and connective tissue growth factor (CTGF) are the pathological features of diabetic nephropathy. In this study, human mesangial cells (HMCs) treated with high glucose showed the above-mentioned features through the activation of Janus kinase 2 (JAK2)/signal transducers and activators of transcription (STAT) pathway. Probucol can suppress cell proliferation, down-regulate mRNA and protein levels of TGF-β1 and CTGF in HMCs treated with high glucose. Phosphorylation of JAK2, STAT1 and STAT3 caused by high glucose was obviously prevented in HMCs pretreated with probucol, indicating that the protective effect of probucol on HMCs might be through the inhibition of JAK2/STAT pathway. Therefore, probucol could be a potential therapeutic agent for diabetic nephropathy, and this paper provides new insights into the molecular mechanisms underlying probucols effects.
- 日本薬学会の論文
著者
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Yao Li
Department Of Pharmacology Kagawa Medical University
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Yao Li
Department Of Oral & Maxillofacial Surgery Toyama Medical & Pharmaceutical Univ.
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Wang Jun
Department Of Electrical Electronic And Information Engineering Osaka University
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Du Juan
Department Of Pathology Peking University Health Science Center
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Wang Lining
Department of Nephrology, First Hospital of China Medical University
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Liu Xiaodan
Department of Nephrology, First Hospital of China Medical University
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Zhou Hongli
Department of Nephrology, First Hospital of China Medical University
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Fan Qiuling
Department of Nephrology, First Hospital of China Medical University
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Luo Jialin
Department of Nephrology, Daqing Oilfield General Hospital
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Feng Jiangmin
Department of Nephrology, First Hospital of China Medical University
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Ma Jianfei
Department of Nephrology, First Hospital of China Medical University
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Wang Lining
Department Of Nephrology The First Hospital Of China Medical University
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Wang Jun
Department Of Chemistry Faculty Of Science And Engineering Saga University
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Wang Jun
Department Of Biochemistry Kagawa University School Of Medicine
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Wang Jun
Department Of Automation And Computer-aided Engineering The Chinese University Of Hong Kong
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Du Juan
Department of Nephrology, First Hospital of China Medical University
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Yao Li
Department of Nephrology, First Hospital of China Medical University
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