Dexmedetomidine premedication attenuates concanavalin A-induced hepatitis in mice
スポンサーリンク
概要
- 論文の詳細を見る
Activated T cells selectively induced by concanavalin A (Con A) in liver are subsequent efficient resolution of inflammation. Activated T cells infiltrating in liver combined with pro-inflammatory cytokines are the major causes in Con A-induced liver injury. In our study, C57/BL mice were injected with Con A combined with dexmedetomidine or not. ALT and AST in blood and histopathology of liver were measured. T cell infiltration in liver was examined by flow cytometry and pro-inflammatory cytokines including IL-6, IL-10, TNF-α, and IFN-γ in blood were measured by ELISA. The mRNA level of CXCL10 was detected by RT-PCR and the protein level of NF-κB was measured by Western-blot. We found that dexmedetomidine alleviated Con A-induced liver injury by down-regulating levels of ALT and AST in blood and the severity of histopathology, which reflect the severity of hepatitis induced by Con A. In addition, pro-inflammatory cytokines in blood were attenuated by dexmedetomidine. Dexmedetomidine restrained the phosphorylation of NF-κB IκBα and P-65 dramatically which may participate in the regulation of cytokines secretion. Moreover, CXCL10 mRNA attenuated by dexmedetomidine in liver may result in the lower level of CD4+ T cells infiltration in liver. These results suggested that dexmedetomidine might be a potential compound in treating T cell-mediated liver injury.
- 一般社団法人 日本毒性学会の論文
著者
-
Wang Jun
Department Of Automation And Computer-aided Engineering The Chinese University Of Hong Kong
-
WANG Haibin
Department of Oral and Maxillofacial Surgery, First Affiliated Hospital of Zhengzhou University
-
Luo Yan
Department of Anesthesiology, Ruijin Hospital, Shanghai JiaoTong University School of Medicine, China
-
Hu Baoji
Department of Anesthesiology and Intensive Care, Changhai Hospital, Second Military Medical University, China
-
Zou Yun
Department of Anesthesiology and Intensive Care, Changhai Hospital, Second Military Medical University, China
-
Bo Lulong
Department of Anesthesiology and Intensive Care, Changhai Hospital, Second Military Medical University, China
-
Li Jinbao
Department of Anesthesiology and Intensive Care, Changhai Hospital, Second Military Medical University, China
関連論文
- Single-Channel Properties of Volume-Sensitive Cl^- Channel in ClC-3-Deficient Cardiomyocytes
- Process Variation Compensation Technique for 0.5-V Body-Input Comparator
- Novel Consecutive-Pilot Design for Phase Noise Suppression in OFDM System
- Training Sequence Design for Low Complexity Channel Estimation in Transmit Diversity TDS-OFDM System
- A multilayer recurrent neural network for solving continuous-time algebraic Riccati equations
- A Novel CPR-TDS-OFDM System for High-Speed Mobile Reception
- Janus Kinase 2/Signal Transducers and Activators of Transcription Signal Inhibition Regulates Protective Effects of Probucol on Mesangial Cells Treated with High Glucose
- Differential ISI Cancellation for TDS-OFDM
- Reversal of P-Glycoprotein Mediated Multidrug Resistance in K562 Cell Line by a Novel Synthetic Calmodulin Inhibitor, E6(Pharmacology)
- Conformational Studies of Cyclo(Pro-Leu-Aib)_2 by ^1H Nuclear Magnetic Resonance Spectroscopy and Circular Dichroism^1
- Synthesis and Solution Conformations of Cyclo(Pro-Leu-Gly)_2 and Cyclo(Pro-Leu-Gly)_4
- Synthesis and Conformational Studies of Cyclic Peptides Containing the C-terminal Tripeptide Sequence of Oxytocin
- Intramolecular Hydrogen-Atom Transfer in 2-Alkylbenzoyloxyl Radicals as Studied by Transient Absorption Kinetics and Product Analyses on the Photodecomposition of Bis(2-alkylbenzoyl) Peroxides
- Intramolecular Hydrogen Atom Transfer in a 2-Methylbenzoyloxyl Radical Revealed by Transient Absorption Kinetics^#
- Juzen-taiho-to, an Herbal Medicine, Activates and Enhances Phagocytosis in Microglia/Macrophages
- Sildenafil Inhibits Human Pulmonary Artery Smooth Muscle Cell Proliferation by Decreasing Capacitative Ca^ Entry
- Radiosensitizing effects of gefitinib at different administration times in vitro
- Expression and Secretion of N-acylethanolamine-hydrolysing Acid Amidase in Human Prostate Cancer Cells
- Direct Observation of the Moving Liquid/Solid Interface during Nanosecond Pulsed Laser Annealing of Silicon
- Khatri-Rao Unitary Space-Time Modulation(Wireless Communication Technologies)
- Absolute exponential stability of recurrent neural networks with Lipschitz-continuous activation functions and time delays
- An LMI approach to global asymptotic stability of the delayed Cohen-Grossberg neural network via nonsmooth analysis
- Pilot Design and Channel Estimation for TDS-OFDM System with Transmit Diversity
- Application of Kelvin Technique in A Gas-Sensor Read-Out Circuit
- Design of a 500-MS/s stochastic signal detection circuit using a non-linearity reduction technique in a 65-nm CMOS process
- A recurrent neural network with exponential convergence for solving convex quadratic program and related linear piecewise equations
- Molecular Structure of Seven - Coordinate trans(O_6)-(Ethylenediamine-N,N'-diacetato-N,N'-di-3-propionato)(aqua)titanate(III), trans(O_6)-[Ti(eddadp)(H_2O)]^-
- A Switched-Capacitor Programmable Gain Amplifier Using Dynamic Element Matching
- A recurrent neural network for solving linear projection equations
- Analysis of adenosine phosphates in HepG-2 cell by a HPLC-ESI-MS system with porous graphitic carbon as stationary phase
- Nucleoside reverse transcriptase inhibitors and their phosphorylated metabolites in human immunodeficiency virus-infected human matrices
- Constraint-Induced Movement Therapy Enhanced Neurogenesis and Behavioral Recovery after Stroke in Adult Rats
- Electrochemical Characteristic of 2-Mercaptobenzothiazole Self-Assembled Monolayer on Gold
- Risk factors for neurodevelopmental deficits in congenital hypothyroidism after early substitution treatment
- Circulating myeloid dendritic cells are increased in individuals with severe aplastic anemia
- A network model for blind source extraction in various ill-conditioned cases
- Anomalous Josephson Current through a Ferromagnet-Semiconductor Hybrid Structure
- Observations on Characterization of Training Errors in Supervised Learning Using Gradient-Based Rules
- Rashba Spin Orbital Coupling Effect on the Conductance of Two-Dimensional Electron Gas/Insulator/Noncentrosymmetric Superconductor Junction
- Wireless on-chip microparticle manipulation using pulse-driven dielectrophoresis
- Effects of Ba Deficiency on Ion Ordering, Grain Growth, and Microwave Dielectric Properties of Ba1-xZn1/3Nb2/3O3 Ceramics
- Electrodeposition of SnO2 Thin Films from Aqueous Tin Sulfate Solutions
- Extrahepatic portal vein aneurysm after orthotopic liver transplantation : a case with 9-year ultrasound observations
- Global exponential stability of recurrent neural networks with time-varying delays in the presence of strong external stimuli
- Huge Solitary Fibrous Tumor of the Pleura with Hypoglycemia and Hypokalemia: A Case Report
- Global exponential periodicity and global exponential stability of a class of recurrent neural networks with various activation functions and time-varying delays
- Meta-analysis of the ADH1B and ALDH2 Polymorphisms and the Risk of Colorectal Cancer in East Asians
- MicroRNAs Contribute to the Anticancer Effect of 1'-Acetoxychavicol Acetate in Human Head and Neck Squamous Cell Carcinoma Cell Line HN4
- Isoflurane Preconditioning Ameliorates Renal Ischemia-Reperfusion Injury through Antiinflammatory and Antiapoptotic Actions in Rats
- Dexmedetomidine premedication attenuates concanavalin A-induced hepatitis in mice
- The role of Tα1 on the infective patients after hematopoietic stem cell transplantation