The Protective Effect of Radicicol Against Renal Ischemia–Reperfusion Injury in Mice
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概要
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Overexpression of heat shock protein 70 kDa (HSP70) is known to confer cellular protection against ischemia–reperfusion (I/R) injury. Radicicol, a HSP90 inhibitor, has been reported to induce the expression of HSP70 protein. Here we studied whether radicicol attenuated renal I/R injury in vivo. Treatment of mice with radicicol ameliorated renal I/R injury and increased renal HSP70 mRNA and protein. Administration of radicicol with quercetin, an inhibitor of HSP70 induction, eliminated the renoprotective effect of radicicol. Our results suggest that the up-regulation of renal HSP70 protein by radicicol leads to a novel drug therapy against renal I/R injury.
著者
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Sonoda Hiroko
Department of Veterinary Pharmacology, Faculty of Agriculture, University of Miyazaki, Japan
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Prachasilchai Worapat
Department of Veterinary Pharmacology, Faculty of Agriculture, University of Miyazaki, Japan
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Kondo Hiroaki
Department of Veterinary Pharmacology, Faculty of Agriculture, University of Miyazaki, Japan
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Yokota-Ikeda Naoko
Department of Internal Medicine, Miyazaki Prefectural Miyazaki Hospital, Japan
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Oshikawa Sayaka
Department of Veterinary Pharmacology, Faculty of Agriculture, University of Miyazaki, Japan
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Ito Katsuaki
Department of Veterinary Pharmacology, Faculty of Agriculture, University of Miyazaki, Japan
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Ikeda Masahiro
Department of Veterinary Pharmacology, Faculty of Agriculture, University of Miyazaki, Japan
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Ito Katsuaki
Department Of Veterinary Pharmacology Faculty Of Agriculture Miyazaki University
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Kondo Hiroaki
Department Of Internal Medicine And Bioregulation Nagoya City University Graduate School Of Medical
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Ikeda Masahiro
Department Of Cardiovascular Surgery Fukui Cardiovascular Center
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Kondo Hiroaki
Department Of Chemistry Biology And Marine Science Faculty Of Science University Of The Ryukyus
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Sonoda Hiroko
Department Of Veterinary Pharmacology Faculty Of Agriculture University Of Miyazaki
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Oshikawa Sayaka
Department Of Veterinary Pharmacology Faculty Of Agriculture University Of Miyazaki
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Prachasilchai Worapat
Department Of Veterinary Pharmacology Faculty Of Agriculture University Of Miyazaki
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Kondo Hiroaki
Department Of Veterinary Pharmacology Faculty Of Agriculture University Of Miyazaki
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Yokota-Ikeda Naoko
Department of Internal Medicine, Miyazaki Prefectural Hospital, Japan
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ITO Katsuaki
Department of Pharmacology, School of Veterinary Medicine, Azabu University
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KONDO Hiroaki
Department of Agricultural Chemistry, Nagoya University
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