The Protective Effect of a Newly Developed Molecular Chaperone–Inducer Against Mouse Ischemic Acute Kidney Injury
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概要
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Activation of the unfolded protein response (UPR) has been suggested to attenuate renal ischemia reperfusion (I/R) injury. We recently found a compound, namely BIX, that activated the UPR selectively through the activating transcription factor 6 pathway. This study examined the effect of BIX on renal I/R injury in mice. BIX selectively up-regulated renal BiP mRNA and protein. Pretreatment with BIX significantly ameliorated renal I/R injury. Co-administration of BIX and tunicamycin, a non-selective UPR inducer, provided no additional protection. Our results suggest that the UPR activation by BIX leads to a novel drug therapy against renal I/R injury.
著者
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Prachasilchai Worapat
Department of Veterinary Pharmacology, Faculty of Agriculture, University of Miyazaki, Japan
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Ito Katsuaki
Department Of Veterinary Pharmacology Faculty Of Agriculture Miyazaki University
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Ikeda Masahiro
Department Of Cardiovascular Surgery Fukui Cardiovascular Center
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Kudo Takashi
Psychiatry Department Of Integrated Medicine Division Of Internal Medicine Osaka University Graduate
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Imaizumi Kazunori
Division Of Molecular And Cellular Biology Department Of Anatomy Faculty Of Medicine University Of M
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Sonoda Hiroko
Department Of Veterinary Pharmacology Faculty Of Agriculture University Of Miyazaki
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Prachasilchai Worapat
Department Of Veterinary Pharmacology Faculty Of Agriculture University Of Miyazaki
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Yokota-Ikeda Naoko
Nephrology Division, Miyazaki Prefectural Miyazaki Hospital
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Imaizumi Kazunori
Division of Molecular and Cellular Biology, Department of Anatomy, Faculty of Medicine, University of Miyazaki, Japan
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Yokota-Ikeda Naoko
Nephrology Division, Miyazaki Prefectural Miyazaki Hospital, Japan
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ITO Katsuaki
Department of Pharmacology, School of Veterinary Medicine, Azabu University
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