Vasorelaxation Effects of 2-Chloroethanol and Chloroacetaldehyde in the Isolated Rat Aortic Rings

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概要

• 論文の詳細を見る

• 2-Chloroethanol (2-CE) is a commonly used solvent in industry; unfortunately, severe hypotension is one of main toxic signs during intoxication. Calcium ion modulation is considered to be an important role of vasorelaxation. The aim of this study is to evaluate either 2-CE or its main metabolite, chloroacetaldehyde (CAA), possible cause of hypotension, by using isolated rat aortic rings. Results revealed that 2-CE caused a weakly relaxation in the phenylephrine (PE) pre-induced endothelium-intact aortic rings. However, its metabolite, CAA induced vasorelaxation and showed dose dependency in endothelium-intact and -denuded aortic rings. The half inhibitory concentration (IC50) of 2-CE exceeded 50 mM; meanwhile, the IC50 values of CAA in the endothelium-intact and -denuded aortic rings were 3.3 and 2.7 mM, respectively. The CAA-induced relaxation could be significantly attenuated by adding calcium (CaCl2) and various Ca2+ channel blockers, dantrolene, nifedipine, and NiCl2. Nifedipine presents the most strong inhibition effect among the calcium blockers. In conclusion, it is suggested that the hypotension effect of 2-CE intoxicated cases may be mainly mediated by its metabolite CAA, and calcium channels are partially involved inducing the vasorelaxation.

• 公益社団法人　日本薬学会の論文

著者

• LIAO Jiunn-Wang

  Graduate Institute of Veterinary Pathobiology, College of Veterinary Medicine, National Chung Hsing

• Cheng Yu-wen

  School Of Pharmacy Taipei Medical Univ.

• Liao Jiunn-wang

  Graduate Inst. Of Veterinary Pathobiology National Chung-hsing Univ.

• Kang Jaw-jou

  Institute Of Toxicology College Of Medicine National Taiwan University

• CHOU Chi-Chung

  Department of Veterinary Medicine, College of Veterinary Medicine, National Chung Hsing University

• Chen Yng-Tay

  Department of Veterinary Medicine, National Chung-Hsing University

• Hung Dong-Zong

  Toxicology Center, China Medical University Hospital, and Graduate Institute of Drug Safety, China M

• Hu Chien-Ming

  Emergency Department, Taipei Medical University Hospital

• Chou Chi-chung

  Department Of Veterinary Medicine And Veterinary Medicine Teaching Hospital College Of Veterinary Me

• Chou Chi-Chung

  Department of Veterinary Medicine, National Chung-Hsing University

• Cheng Yu-Wen

  School of Pharmacy, Taipei Medical University

• Liao Jiunn-Wang

  Graduate Institute of Veterinary Pathobiology, National Chung-Hsing University

• Hungq Dong-Zong

  Toxicology Center, China Medical University Hospital, and Graduate Institute of Drug Safety, China Medical University

• Chen Yng-Tay

  Department of Pediatrics, Medical Research and Medical Genetics, China Medical College Hospital

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