Chloroacetaldehyde Induces Chromosome Aberrations and Micronucleus Formation but Not 2-chloroethanol

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概要

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• 2-Chloroethanol (2-CE) has been used on grapevines to accelerate grape growth, and its metabolite, chloroacetaldehyde (CAA), accumulated in the liver and blood from rats intoxicated with 2-CE. Chronic occupational injury might be a possible reason for the 2-CE intoxication. In this study, we used the in vitro and in vivo tests to examine the genotoxicity of 2-CE and CAA. First, 2-CE did not induce chromosome aberration formation in Chinese ovary hamster cells, but CAA did induce chromosome aberration formation, especially the chromosome gap-type aberration after S9 activation. Second, 2-CE at high doses (1/2 LD50), but not at low doses, induced peripheral blood micronucleus formation in mice. CAA induced micronucleus formation at low and high dosages (1/8-1/2 LD50). These results indicated that CAA plays an important role in 2-CE chronic intoxication, and the genotoxic mechanisms of CAA require further study.

• 公益社団法人　日本薬学会の論文

著者

• Liao Jiunn-wang

  Graduate Inst. Of Veterinary Pathobiology National Chung-hsing Univ.

• Hsu Ching-I

  The Animal Disease Diagnostic Center, National Chung-Hsing University

• Matsuura Isao

  Division of Molecular and Genomic Medicine, National Health Research Institutes

• Chen Yng-Tay

  Division of Molecular and Genomic Medicine, National Health Research Institutes

• Liao Jiunn-Wang

  Graduate Institute of Veterinary Pathobiology, National Chung-Hsing University

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