Extracellular heat shock proteins (eHSPs) pilot exogenous antigen into cross-presentation pathway: A superguide from extracellular world to intracellular tour
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概要
- 論文の詳細を見る
Heat shock proteins (HSPs) are intracellular chaperone, some of which function as immune adjuvants as well as danger signals for immune system when released into extracellular milieu. These HSPs, along with their client polypeptides, are specifically bound by receptors on antigen presenting cells (APCs). This leads to APC differentiation along with delivery of the chaperoned peptides for cross-presentation to T cells. HSP-APC interactions occur through several receptors that mediate endocytosis or signal transduction. Most importantly, HSP associated antigens are forced to enter the cross-presentation pathway by APCs, resulting in CD8+ T cell activation. These unique features of HSPs for the generation of immune response will be discussed.
- 日本癌病態治療研究会の論文
著者
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Kutomi Goro
Department Of Breast Surgery Cancer Institute Hospital
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Tamura Yasuaki
Department Of Gastroenterology Sapporo Medical University
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Sato Noriyuki
Department Of Biological Chemistry Faculty Of Agriculture Yamaguchi University
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Torigoe Toshihiko
Department of First Pathology, Sapporo Medical University School of Medicine, Sapporo 060-8556, Japan
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Torigoe Toshihiko
Department of Pathlogy, Sapporo Medical University, School of Medicine
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Oura Jun
Department of Pathlogy, Sapporo Medical University, School of Medicine
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Tamura Yasuaki
Department of Pathlogy, Sapporo Medical University, School of Medicine
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Kutomi Goro
Department of Pathlogy, Sapporo Medical University, School of Medicine
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Sato Noriyuki
Department of Pathlogy, Sapporo Medical University, School of Medicine
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