Quantitative Analysis of Saponins in a Tea-Leaf Extract and Their Antihypercholesterolemic Activity
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概要
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A novel simple method using liquid chromatography/time-of-flight mass spectrometry (LC/TOF-MS) and LC/UV was established for the quantification of saponins in an extract from green tea leaves. The amount of saponins in a fraction with high in vitro antihypercholesterolemic activity, Fr2-3, was determined to be 72%. An in vivo experiment showed that the addition of 0.5% Fr2-3 to a high-cholesterol diet suppressed the increase in serum cholesterol levels in rats. Fr2-3 induced a decrease in the liver cholesterol and triglyceride levels and an increase in the fecal excretion of cholesterol. These results indicate tea-leaf saponins to be the active components in Fr2-3 and that these saponins exhibited antihypercholesterolemic activity by inhibiting cholesterol absorption in the intestines.
著者
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KUMAGAI Hitomi
Department of Chemistry and Life Science, Nihon University
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Matsui Yoko
Laboratory of Health Materials, Functional Ingredient Department, Ogawa & Co., Ltd.
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Kobayashi Keiko
Laboratory of Health Materials, Functional Ingredient Department, Ogawa & Co., Ltd.
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Masuda Hideki
Laboratory of Health Materials, Functional Ingredient Department, Ogawa & Co., Ltd.
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KIGOSHI Hideo
Department of Chemistry, Graduate School of Pure and Applied Sciences, University of Tsukuba
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AKAO Makoto
Department of Agricultural and Biological Chemistry, Nihon University
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SAKURAI Hidetoshi
Department of Agricultural and Biological Chemistry, Nihon University
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Matsui Yoko
Material R&d Laboratory Ogawa & Co. Ltd.
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Masuda Hideki
Dep. Of Food And Nutritional Sciences Graduate School Of Nutritional And Environmental Sciences And
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Kato Keiko
Nihon University
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