Fibulin-5 Contributes to Microfibril Assembly in Human Periodontal Ligament Cells

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概要

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• The elastic system fibers comprise oxytalan, elaunin and elastic fibers, which differ in their relative microfibril and elastin content. Human periodontal ligaments (PDL) contain only oxytalan fibers (pure microfibrils) among them. Since fibulin-5 regulates the organization of elastic fibers to link the fibers to cells, we hypothesized that fibulin-5 may contribute to the formation of oxytalan fibers. We used siRNA for fibulin-5 in PDL cell culture to examine the extracellular deposition of fibrillin-1 and -2, which are the major components of microfibrils. Fibulin-5 was labeled on microfibrils positive for fibrillin-1 and -2. Fibulin-5 suppression reduced the level of fibrillin-1 and -2 deposition to 60% of the control level. These results suggest that fibulin-5 may control the formation of oxytalan fibers, and play a role in the homeostasis of oxytalan fibers.

• 日本組織細胞化学会の論文

著者

• Ishikawa Hiroyuki

  Section Of Orhodontics Department Of Oral Growth Development Division Of Clinical Dentistry Fukuoka

• Tsuruga Eichi

  Section of Functional Structure, Department of Morphological Biology, Division of Biomedical Sciences, Fukuoka Dental College

• Sawa Yoshihiko

  Section of Functional Structure, Department of Morphological Biology, Division of Biomedical Sciences, Fukuoka Dental College

• Hatakeyama Yuji

  Section of Functional Structure, Department of Morphological Biology, Division of Biomedical Sciences, Fukuoka Dental College

• Hisanaga Yutaka

  Section of Orthodontics, Department of Oral Growth & Development, Division of Clinical Dentistry, Fukuoka Dental College

• Nakashima Kazuki

  Section of Orthodontics, Department of Oral Growth & Development, Division of Clinical Dentistry, Fukuoka Dental College

• Nakatomi Yuka

  Section of Orthodontics, Department of Oral Growth & Development, Division of Clinical Dentistry, Fukuoka Dental College

• Nakashima Kazuki

  Section of Orthodontics, Department of Oral Growth & Development, Division of Clinical Dentistry, Fukuoka Dental College

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• Matrix Metalloproteinase-2 Degrades Fibrillin-1 and Fibrillin-2 of Oxytalan Fibers in the Human Eye and Periodontal Ligaments In Vitro
• Fibulin-5 Contributes to Microfibril Assembly in Human Periodontal Ligament Cells

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