Participation of Proteinase-Activated Receptor-2 in Passive Cutaneous Anaphylaxis-Induced Scratching Behavior and the Inhibitory Effect of Tacrolimus
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概要
- 論文の詳細を見る
Proteinase-activated receptor-2 (PAR2) may be an important regulator of skin mast cell function during cutaneous inflammation and hypersensitivity. However, little is known of the role of PAR2 in allergic pruritus, because mast cells, which are thought to be responsible for this symptom, can release a number of different pruritogens. In the present study, we investigated the effects of several agents on passive cutaneous anaphylaxis-induced scratching behavior in ICR mice. As a result, cetirizine and ketanserin produced dose-dependent inhibition of scratching behavior induced by passive cutaneous anaphylaxis. Combined cetirizine with ketanserin exhibited significant inhibitory effects for the number of passive cutaneous anaphylaxis-induced scratching behavior. Pretreatment of the experimental animals with PAR2-neutralizing antibody and protease inhibitor leupeptin significantly inhibited passive cutaneous anaphylaxis-induced scratching behavior. Furthermore, we found that topical application of tacrolimus significantly reduced the number of scratching behavior induced by passive cutaneous anaphylaxis in a dose-dependent manner. Combined cetirizine with tacrolimus also exhibited significant inhibitory effects for the number of passive cutaneous anaphylaxis-induced scratching behavior. Tacrolimus in doses of 3% and 10% significantly inhibited tryptase-induced scratching behavior. These results suggest that PAR2 may be involved in passive cutaneous anaphylaxis-induced scratching behavior and tacrolimus produces an anti-allergic pruritus effect in ICR mice.
- 日本薬学会の論文
著者
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WU Jian
Department of Pharmacology, School of Pharmacy, Second Military Medical University
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Xu Jian
Department Of Electronic Engineering The Chinese University Of Hong Kong
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LIU Yan
Department of Nutrition and Food Hygiene, School of Public Health, Nanjing Medical University
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Li Feng
Department Of Radiology Shinshu University School Of Mmedicine
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Xu Jian
Department Of Anatomy And Histology School Of Basic Sciences Peking University
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Zhu Yu
Department of Pharmacy, Changhai Hospital, the Second Military Medical University
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Peng Cheng
Department of Pharmacy, Changhai Hospital, the Second Military Medical University
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Zhu Quan
Department of Pharmacy, Changhai Hospital, the Second Military Medical University
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Liu Ji
Department of Pharmacy, Changhai Hospital, the Second Military Medical University
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Hu Jin
Department of Pharmacy, Changhai Hospital, the Second Military Medical University
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Zhu Yu
Department Of Communication Science And Engineering Fudan University
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Liu Yan
Department Of Cardiology Daping Hospital The Third Military Medical University
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Hu Jin
Department Of Animal Science Division Of Bio-productive Science Faculty Of Agriculture Utsunomiya Un
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Peng Cheng
Department Of General Surgery Qilu Hospital Shandong University
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Li Feng
Department Of Cardiothoracic Surgery The Second Xiang Ya Hospital Of Central South University
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Wu Jian
Department Of Electronic Chemistry Interdisciplinary Graduate School Of Science And Engineering Toky
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Wu Jian
Department Of Applied Biology & Chemical Technology The Hong Kong Polytechnic University
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Zhu Yu
Department Of Chemistry University Of Science And Technology Of China
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Wu Jian
Department of Dermatology, Changhai Hospital, the Second Military Medical University
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Xu Jian
Department of Pharmacy, Changhai Hospital, the Second Military Medical University
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Li Feng
Department of Pharmacy, Changhai Hospital, the Second Military Medical University
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Liu Yan
Department of Pharmacy, Changhai Hospital, the Second Military Medical University
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Liu Yan
Department of Applied Physics, South China Agricultural University, Guangzhou 510642, China
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Zhu Quan
Department of Cardiothoracic Surgery, the First Affiliated Hospi tal of Nanjing Medical University, Nanjing, China
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