Tiotropium Ameliorates Symptoms in Patients with Chronic Airway Mucus Hypersecretion which is Resistant to Macrolide Therapy
スポンサーリンク
概要
- 論文の詳細を見る
Objective Low-dose, long-term macrolide therapy has been shown to be effective for the treatment of diffuse panbronchiolitis (DPB) and similar disorders in terms of the presence of airway mucus hypersecretion such as bronchiectasis, chronic bronchitis and sinobronchial syndrome. However, there are some patients, especially advanced cases, whose volume of sputum does not decrease sufficiently with macrolide therapy. These patients suffer from copious expectoration. There is currently no effective treatment, and an effective therapy is therefore urgently required. The aim of this study was to clarify whether or not the inhalation of tiotropium improves the symptoms in these cases. Methods Tiotropium (18 μg/day) was administered to patients with DPB and similar disorders with airway mucus hypersecretion who did not respond to macrolide. The symptoms were evaluated by a visual analog scale (VAS) prior to and at 1 and 3 months after tiotropium administration. Radiological and pulmonary function tests were also performed to evaluate the effects of tiotropium. Results Thirteen patients (DPB 5, sinobronchial syndrome 5, bronchiectasis 3) were enrolled. The VAS scores were dramatically improved after the introduction of tiotropium. FEV1 was significantly improved after 3 months of treatment with tiotropium. In contrast, the radiological findings remained unchanged. Conclusion Tiotropium improved the symptoms of cough, sputum and breathlessness in the macrolide-resistant cases of DPB or similar disorders. These beneficial effects might be due to the suppression of airway secretion through the anticholinergic effect of tiotropium on the submucosal gland, however, the long-term efficiency of this treatment still needs to be further assessed.
著者
-
FUJITA KAZUE
Department of Biology, Faculty of Science, Ibaraki University
-
Morimoto Taisuke
Department Of Endodontics School Of Dentistry Aichi-gakuin University
-
Azuma Arata
Department Of Internal Medicine Nippon Medical School
-
Usuki Jiro
Department Of Pathology Nippon Medical School
-
Abe Shinji
Department Of Clinical Pharmacy Tokushima University Hospital
-
Motegi Takashi
Department Of Internal Medicine Division Of Pulmonary Medicine Infectious Diseases And Oncology Nippon Medical School Respiratory Care Clinic Nippon Medical School
-
SAITO Yoshinobu
Department of Industrial Chemistry, Faculty of Engineering, Tokyo University of Science
-
Saito Yoshinobu
Department of Internal Medicine (Divisions of Pulmonary Medicine, Infectious Diseases, and Oncology), Nippon Medical School
-
Kudoh Shoji
Department of Internal Medicine (Divisions of Pulmonary Medicine, Infectious Diseases, and Oncology), Nippon Medical School
-
Usuki Jiro
Department of Internal Medicine (Divisions of Pulmonary Medicine, Infectious Diseases, and Oncology), Nippon Medical School
-
Azuma Arata
Department of Internal Medicine (Divisions of Pulmonary Medicine, Infectious Diseases, and Oncology), Nippon Medical School
-
Fujita Kazue
Department of Internal Medicine (Divisions of Pulmonary Medicine, Infectious Diseases, and Oncology), Nippon Medical School
関連論文
- Three Cases of Intractable Pneumothorax Treated Successfully with Bronchial Occlusion Using Endobronchial Watanabe Spigots and Coagulation Factor XIII
- Oxidation of Molecular Tritium by Surface Soils
- Calcium and Reactive Oxygen Species Mediated Zn^-Induced Apoptosis in PC12 Cells
- S12-4 Zinc-induced cytotoxicity in PC12 cells(SYMPOSIUM 12: OXIDATIVE STRESS AND ORGAN DAMAGE)(Proceedings of the 31st Annual Meeting)
- The Reaction Rate of Edaravone (3-Methyl-1-phenyl-2-pyrazolin-5-one (MCI-186)) with Hydroxyl Radical
- Production design and evaluation of a novel breast phantom with various breast glandular fractions
- Effects of Density Changes in the Chest on Lung Stereotactic Radiotherapy
- Measurements of energy dependence in image detectors using monochromatized X-ray
- The calculation of diagnostic X-ray spectra and other date using the Spectrum Processor
- Residual range distribution measured by heavy ion radiography
- Development of X-ray Spectroscopic System Using Medical X-ray Tube
- Dose distribution for the stereotactic irradiation using Monte Carlo simulation
- Tiotropium Ameliorates Symptoms in Patients with Chronic Airway Mucus Hypersecretion which is Resistant to Macrolide Therapy
- Fundamental Characteristics for Absorbed Dose Calculations of Stereotactic Irradiation
- Pyothorax-associated lymphoma : Development of Epstein-Barr virus-associated lymphoma within the inflammatory cavity
- Early phase ll study of S-1, a new oral fluoropyrimidine, for advanced non-small-cell lung cancel
- Phagocytosis of co-developing neutrophil progenitors by dendritic cells in a culture of human CD34^+ cells with granulocyte colony-stimulating factor and tumor necrosis factor-α
- Choledochojejunorrhaphy with Internal T-tube Splint of Silicone Rubber
- Effects of Angiotensin II Type 1 Receptor Blockade on the Systemic Blood Nitric Oxide Dynamics in N^ω-Nitro-L-Arginine Methyl Ester-Treated Rats
- Right Hepatic LObectomy for Hepatocellular Carcinoma Which Developed in Primary Biliary Cirrhosis: Report of a Case
- Management of adrenal metastasis of hepatocellular carcinoma by asynchronous resection of bilateral adrenal glands
- Nine-Year survivor after resection of cholangiocellular carcinoma with tumor thrombi in the main portal trunk
- Extent of Emphysema on HRCT Affects Loss of Fat-free Mass and Fat Mass in COPD
- The Value and Limitation of Transbronchial Lung Biopsy for the Diagnosis of Diffuse Interstitial Lung Diseases(Bronchoscopy in Non-tumorous Pulmonary Disorders)(The 23rd Annual Congress of the Japan Society for Bronchology)
- Efficacy of Directional Coronary Atherectomy Prior to Stenting forthe Ostial Lesion of the Left Anterior Descending Coronary Artery
- Mediastinal yolk sac tumor in a woman
- Angiotropic B-Cell Lymphoma with Telangiectasia, Accompanied by Panniculitic Formation
- Dynamic Helical CT Mammography of Breast Cancer
- Accumulation of ^Tc-PMT in renal metastasis of hepatocellular carcinoma
- A case of pediatric gastrointestinal stromal tumor of the stomach
- Application of Intravascular Ultrasonography for Intracaval Tumor Thrombectomies in Adrenal Metastasis from Hepatocellular Carcinoma: Report of Two Cases
- Emphysema on imaging is associated with quality of life in elderly patients with chronic obstructive pulmonary disease
- Microbial substitution of Mycobacterium avium-intracellulare to Mycobacterium abscessus during clinical course
- Correlation between Bronchodilator Responsiveness and Quality of Life in Chronic Obstructive Pulmonary Disease
- STUDY ON A NEWLY DEVELOPED TITANIUM OXIDE SEALER
- Atypical liver hemangioma with shunt : long-term follow-up
- Bi-Local Model with Additional Internal Dynamical Variables and Interaction with External Fields : Particles and Fields
- A Case of Hepatitis C-Associated Osteosclerosis with Xanthogranulomatous Cholecystitis
- Relation of C-Reactive Protein and Statin Therapy to the Rate of Progression of Aortic Valve Stenosis
- Concerns with the Health Check-up System for Chronic Obstructive Pulmonary Disease on two Japanese Islands
- Evolution of three patterns of intra-alveolar fibrosis produced by bleomycin in rats
- A Prospective and Randomized Study for Improvement of Acute Asthma by Non-invasive Positive Pressure Ventilation (NPPV)
- A Case of Bucillamine-induced Interstitial Pneumonia with Positive Lymphocyte Stimulation Test for Bucillamine Using Bronchoalveolar Lavage Lymphocytes
- New Non-invasive Automatic Cough Counting Program Based on 6 Types of Classified Cough Sounds
- Efficient integrated education for older patients with chronic obstructive pulmonary disease using the Lung Information Needs Questionnaire
- A Case of Neurofibromatosis Type 1 Coinciding with Bilateral Pheochromocytomas, Multiple Gastrointestinal Stromal Tumors, and Malignant Peripheral Nerve Sheath Tumor
- Proportion of Rectal Carriage of Extended-Spectrum β-Lactamase-Producing Enterobacteriaceae in the Inpatients of a Pediatric Tertiary Care Hospital in Japan
- Granuloma-forming Interstitial Pneumonia Occurring One Year after the Start of Everolimus Therapy
- Fabrication of μ-DMFCs with a Tubular Polymer Electrolyte by Catalyst Pasting Method and Their Performance
- Successful Treatment of Histiocytic Sarcoma and Concurrent HIV Infection Using a Combination of CHOP and Antiretroviral Therapy