Decompensated Lamivudine-resistant Hepatitis B Virus-related Cirrhosis Treated Successfully with Adefovir Dipivoxil Allowing Surgery for Hepatocellular Carcinoma
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概要
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We describe a 64-year-old man with decompensated hepatitis B virus (HBV)-related cirrhosis who became resistant to lamivudine. He was started on adefovir at 10 mg daily while continuing lamivudine therapy. Several months later, his liver function improved and subsequently his ascites disappeared. The serum HBV-DNA level became undetectable 11 months later. Twenty months after the start of additional treatment with adefovir, one hepatocellular carcinoma (HCC) was detected, and the patient underwent a successful hepatectomy. Our findings suggest that the addition of adefovir to ongoing lamivudine therapy is useful for improving liver function in patients with decompensated lamivudine-resistant HBV-related cirrhosis, allowing surgery for HCC.
著者
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ICHIDA Takafumi
Department of Gastroenterology, Juntendo University School of Medicine, Shizuoka Hospital
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Aoyagi Yutaka
Department Of Gastroenterology And Hepatology Niigata University Graduate School Of Medical And Dent
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Uehara Kazuhiro
Department Of Applied Chemistry The University Of Tokyo
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Nomoto Minoru
Department Of Gastroenterology And Hepatology Graduate School Of Medical And Dental Sciences Niigata
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Ichida Takafumi
Department Of Gastroenterology And Hepatology Juntendo University Shizuoka Hospital
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Osaki Akihiko
Department Of Breast Oncology International Medical Center Saitama Medical University
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NOMOTO Minoru
Department of Gastroenterology and Hepatology, Graduate School of Medical and Dental Sciences, Niigata University
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Ohkoshi Shogo
Department of Gastroenterology and Hepatology, Graduate School of Medical and Dental Sciences, Niigata University
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Takamura Masaaki
Department of Gastroenterology and Hepatology, Graduate School of Medical and Dental Sciences, Niigata University
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Tsubata Shunsuke
Department of Gastroenterology and Hepatology, Graduate School of Medical and Dental Sciences, Niigata University
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Aoyagi Tomoya
Department of Gastroenterology and Hepatology, Graduate School of Medical and Dental Sciences, Niigata University
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Terada Haruo
Department of Internal Medicine, Niigata Rinko Hospital
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Osaki Akihiko
Department of Gastroenterology and Hepatology, Graduate School of Medical and Dental Sciences, Niigata University
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