Changes in CCR2 Chemokine Receptor Expression and Plasma MCP-1 Concentration after the Implantation of Bare Metal Stents Versus Sirolimus-eluting Stents in Patients with Stable Angina
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概要
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Background Although restenosis after successful coronary stenting is associated with changes in adhesion molecules and chemokines, it is unclear whether the differential effects of these molecules between a bare metal stent (BMS) and sirolimus-eluting stent (SES) may help to prevent coronary restenosis. The aim of this clinical study was to compare the expression levels of those molecules after elective placement of either a BMS or SES. Methods and Results The subjects included 32 consecutive patients with stable angina who had undergone successful coronary stenting and who randomly received either a BMS (n=16) or SES (n=16). Quantitative angiographic analysis 6 months after stenting showed that the minimal lumen diameter was significantly greater in the SES as compared to the BMS group, while the percent diameter stenosis and in-stent lumen loss were significantly lower. Plasma monocyte chemotactic protein-1 (MCP-1) increased significantly after 14 days and 6 months and monocyte CCR2 expression increased 24 hr and 48 hr after stenting in the BMS but not the SES group. Changes in plasma MCP-1 (ΔMCP-1) within 6 months after stenting correlated significantly with in-stent lumen loss. The ΔMCP-1 (between 6 months and baseline) was significantly related only to the lumen loss (r=0.443, p=0.023), which suggests that the reduction of MCP-1 is the best contributor to decreased lumen loss. Conclusions These data suggest that reduction in MCP-1 production by SES may be one mechanism to prevent restenosis after coronary stenting.
- 社団法人 日本内科学会の論文
著者
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Nishikawa Hiroaki
Department Of Cardiology Faculty Of Medicine Fukuoka University
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Matsuo Kunihiro
Department of Cardiology, Fukuoka University School of Medicine
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Shirai Kazuyuki
Department Of Cardiology Faculty Of Medicine Fukuoka University
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Matsuo Kunihiro
Department Of Cardiology Fukuoka University Hospital School Of Medicine
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Sako Hideto
Department Of Cardiology Fukuoka University School Of Medicine
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Kawamura Akira
Department Of Applied Electronics Faculty Of Electro-communications University Of Electro-communicat
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Saku Keijiro
Department Of Cardiology Faculty Of Medicine Fukuoka University
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Miura Shin-ichiro
Department Of Cardiology Faculty Of Medicine Fukuoka University
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Iwata Atsushi
Department Of Biological Sciences Stanford University
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Sako Hideto
Department of Cardiology, Fukuoka University School of Medicine
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