Efficacy of Edaravone in Cardioembolic Stroke

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概要

• 論文の詳細を見る

• Objective: We investigated the efficacy of edaravone in patients with cardioembolic stroke. Methods: Cardioembolic stroke patients were treated with drip intravenous infusion of edaravone (ED group, n=141) for 7 days, and were retrospectively compared with a historicalcontrolled cohort of similar patients (control group, n=114). Results: Early improvement (between day 0 and day 10), defined as change in National Institutes of Health Stroke Scale (NIHSS), was seen more frequently in mild patients (NIHSS on admission ≤7) among the ED group than in the control group (change in NIHSS +2 vs. -2, respectively, p=0.013). Similar efficacy was not seen in the moderate to severe (NIHSS >7) patients. Independent patients (modified Rankin Scale ≤2) 6 months after the onset were likely to be less frequent in the ED than the control group (28% versus 41%; p=0.066). Other clinical outcomes in the ED group were not significantly different from those in the control group. Conclusion: The results suggest that edaravone may only be effective in mild patients with cardioembolic stroke.

• 社団法人 日本内科学会の論文

著者

• Fujioka Shodo

  Stroke Center Saiseikai Kumamoto Hospital

• Uchino Makoto

  Department Of Neurology Graduate School Of Medical Sciences Kumamoto University

• HASHIMOTO Yoichiro

  Department of Neurology, Kumamoto City Hospital

• Hirano Teruyuki

  Department Of Neurology Graduate School Of Medical Science Kumamoto University

• Inatomi Yuichiro

  Stroke Center Saiseikai Kumamoto Hospital

• Yonehara Toshiro

  Stroke Center Saiseikai Kumamoto Hospital

• Takita Tomohiro

  Stroke Center, Saiseikai Kumamoto Hospital

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