Gender Difference in the Level of Highdensity Lipoprotein Cholesterol in Elderly Japanese Patients with Coronary Artery Disease
スポンサーリンク
概要
- 論文の詳細を見る
Objective: Highdensity lipoprotein cholesterol (HDLC) levels are known to be reduced in the metabolic syndrome, but the HDLC profile of elderly patients with coronary artery disease (CAD) has not been well characterized. This study investigated the gender difference of HDLC levels in elderly Japanese patients with CAD. Methods: Serum lipid data were analyzed retrospectively to assess sexrelated differences of the lipid profile, and to evaluate the effects of pharmacotherapy or physical exercise on hyperlipidemia. Patients: A total of 163 elderly (≥65 years) outpatients with CAD (128 men aged 70.6±5.2 years and 35 women aged 74.1±6.0 years [mean±SD]) were investigated. Results: The mean total cholesterol (TC), lowdensity lipoprotein cholesterol (LDLC), and triglyceride (TG) levels were similar in men and women, while the mean HDLC level was significantly higher in women than men (58.3±18.1 vs. 50.3±13.5 mg/dL; p=0.0064). The HDLC level was not significantly influenced by oral lipidlowering therapy or regular exercise in either sex. However, women without lipidlowering therapy had significantly higher HDLC levels than men with (p=0.0312) or without (p=0.0338) lipidlowering therapy, while women performing regular exercise had significantly higher HDLC levels than men with (p=0.0047) or without (p<0.001) regular exercise. Conclusion: Elderly women with CAD have higher HDLC levels relative to their postmenopausal state than those of men with CAD. Low HDLC levels, unlike in men, may not be a major risk factor for CAD in elderly women.
著者
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Kida Keisuke
Department of Cardiology, St. Marianna University School of Medicine
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Inoue Koji
Department of Cardiology, St.Mariannna University School of Medicine
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Hashimoto Nobuyuki
Department Of Cardiology St.marianna University School Of Medicine
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Akashi Yoshihiro
Department Of Cardiology St. Marianna University Yokohama-city Seibu Hospital
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Hayashi Akio
Department Of Electrical Engineering Chubu University
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Suzuki Kae
Department Of Cardiovascular Internal Medicine St. Marianna University School Of Medicine Hospital
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Kawasaki Kensuke
Department Of Cancer And Thoracic Surgery Okayama University School Of Medicine
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Yamauchi Masahiro
Department Of Agricultural Chemistry Faculty Of Agriculture Tohoku University
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Musha Haruki
Department Of Cardiology St. Marianna University School Of Medicine
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Takahashi Eiji
Department Of Biology Faculty Of Science Kobe University
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Kunishima Tomoyuki
Department Of Cardiology St. Marianna University School Of Medicine
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Tsuchiya Katsuhiko
Department Of Cardiology St. Marianna University Yokohama City Seibu Hospital
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Kunishima Tomoyuki
Department of Cardiology, Yokohama City Seibu Hospital, St. Marianna University School of Medicine
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Akashi Yoshihiro
Department of Cardiology, Yokohama City Seibu Hospital, St. Marianna University School of Medicine
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Hayashi Akio
Department of Cardiology, Yokohama City Seibu Hospital, St. Marianna University School of Medicine
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Suzuki Kae
Department of Cardiology, Yokohama City Seibu Hospital, St. Marianna University School of Medicine
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Kawasaki Kensuke
Department of Cardiology, Yokohama City Seibu Hospital, St. Marianna University School of Medicine
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Hashimoto Nobuyuki
Department of Cardiology, Yokohama City Seibu Hospital, St. Marianna University School of Medicine
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Takahashi Eiji
Department of Applied Chemistry, Faculty of Engineering, Kanagawa University
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Takahashi Eiji
Department of Cardiology, Yokohama City Seibu Hospital, St. Marianna University School of Medicine
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