Impact of Statin Therapy on Systemic Inflammation, Left Ventricular Systolic and Diastolic Function and Prognosis in Low Risk Ischemic Heart Disease Patients without History of Congestive Heart Failure
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概要
- 論文の詳細を見る
Objectives The aim of this study was to investigate the impact of statin on systemic inflammation, left ventricular systolic and diastolic function and prognosis in low risk ischemic heart disease (IHD) patients. Methods A total of 430 consecutive IHD patients without congestive heart failure were enrolled. One hundred and thirtytwo patients (31%) were treated with statin (statin group) and 298 patients (69%) were not (no statin group). Echocardiographic indices, high sensitivity CRP, and prognosis were compared. Results Ejection fraction (EF) was significantly higher in the statin group (p<0.01). The ratio of the early transmitral flow velocity to early diastolic velocity of the mitral annulus (E/E) was significantly lower in the statin group than in the no statin group (p<0.01). Although LDL-cholesterol level did not differ, high sensitivity CRP level was significantly lower in the statin group (0.3±0.5 vs. 1.1±2.3 mg/dl, p=0.005). Cardiac event-(cardiac death and congestive heart failure)free survival rate was significantly higher in the statin group than in no statin group (Log-rank p<0.0001). By multivariate logistic regression analysis, E/E> 15 (p=0.002), EF < 50% (p=0.003), lack of statin use (p=0.009), left atrial dimension (p=0.02), use of diuretics (p=0.03) and lack of beta-blockers (p=0.04) were independent predictors of cardiac events. In 248 patients matched by propensity scores, statin remained associated with better event-free survival (Log-rank p=0.006). Conclusion Statin may improve left ventricular function and thus improve the prognosis in low risk patients with IHD.
- 社団法人 日本内科学会の論文
著者
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Taguchi Haruyuki
Division Of Cardiology Bell Land General Hospital
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OKURA Hiroyuki
Division of Cardiology, Kawasaki Medical School
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YOSHIDA Kiyoshi
Division of Cardiology, Kawasaki Medical School
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Kubo Tomoichiro
Division of Cardiology, Bell Land General Hospital
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Asawa Koichiro
Division of Cardiology, Bell Land General Hospital
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Toda Iku
Division of Cardiology, Bell Land General Hospital
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Toda Iku
Division Of Cardiology Bell Land General Hospital
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Yoshiyama Minoru
Division of Cardiology, Osaka City University School of Medicine
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Yoshikawa Junichi
Division of Internal Medicine and Cardiology, Osaka Ekisaikai Hospital
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Asawa Koichiro
Division Of Cardiology Bell Land General Hospital
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Yoshida Kiyoshi
Division Of Cardiology Kawasaki Medical School
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Okura Hiroyuki
Division Of Cardiology Bell Land General Hospital
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Yoshiyama Minoru
Division Of Cardiology Department Of Internal Medicine Graduate School Of Medicine Osaka City Univer
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YOSHIKAWA Junichi
Division of Cardiology, Nishinomiya Watanabe Cardiovascular Center
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Yoshiyama Minoru
Division of Internal Medicine and Cardiology, Osaka City University Medical School
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Taguchi Haruyuki
Division of Cardiology, Bell Land General Hospital
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