Anti-inflammatory Effect of Theophylline in Rats and Its Involvement of the Glucocorticoid-Glucocorticoid Receptor System
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概要
- 論文の詳細を見る
Although theophylline has been suggested to have an anti-inflammatory effect, there have been few reports to show the in vivo effect and the mechanism of anti-inflammatory activity of theophylline experimentally. To reveal the anti-inflammatory activity of theophylline, we studied the effect of theophylline and its metabolites on carrageenan-induced edema in rat foot pad. Subcutaneous injection of theophylline (5 – 100 mg/kg) inhibited carrageenan-induced edema dose-dependently. Theophylline metabolites, that is, 1-methylxanthine, 3-methylxanthine, 1-methyluric acid, and 1,3-dimethyluric acid (equimolar dose to 50 mg/kg of theophylline), did not inhibit the edema significantly. The inhibitory effect of theophylline on carrageenan-induced edema disappeared by pretreatment with aminoglutethimide, an inhibitor of glucocorticoid synthesis and with mefepristone, an antagonist of the glucocorticoid receptor. These results suggest that theophylline itself has anti-inflammatory activity and the glucocorticoid–glucocorticoid receptor system is involved in the anti-inflammatory activity of theophylline.
著者
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Tsuchiya Masao
Department of Cardiol, Jichi Medical School
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Kizu Junko
Department Of Pharmacy Branch Hospital Faculty Of Medicine University Of Tokyo
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Hori Seiji
Department Of Academic Surgery (m9) Graduate School Of Medicine Chiba University
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Watanabe Shigekazu
Department Of Pharmacy Branch Hospital Faculty Of Medicine University Of Tokyo
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Terajima Tomoko
Department Of Molecular Pharmacology And Pharmacotherapeutics Graduate School Of Pharmaceutical Scie
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Yamakami Jun
Department Of Practical Pharmacy Kyoritsu University Of Pharmacy
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Watanabe Shigekazu
Department of Practical Pharmacy, Kyoritsu University of Pharmacy, Japan
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Kizu Junko
Department of Practical Pharmacy, Kyoritsu University of Pharmacy, Japan
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Yamakami Jun
Department of Practical Pharmacy, Kyoritsu University of Pharmacy, Japan
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Tsuchiya Masao
Department of Practical Pharmacy, Kyoritsu University of Pharmacy, Japan
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Terajima Tomoko
Department of Practical Pharmacy, Kyoritsu University of Pharmacy, Japan
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