A New Theophylline Ointment with Rapid and High Transdermal Delivery
スポンサーリンク
概要
- 論文の詳細を見る
A transdermal therapeutic system (TTS) for the delivery of theophylline would be useful for treating bronchial asthma. especially in the case of asthma attacks in outpatients. We prepared several new types of theophylline and aminophylline ointments using transdermal absorption enhancers and measured the in vivo transdermal absorption efficiency of theophylline in ruts. Among the ointments tested, a washable ointment of theophylline with N-methyl-2-pyrrolidone as a solvent and isopropyl myristate as an absorption enhancer showed the best results. The highest absorption was obtained with a concentration of 2% theophylline and 57% isopropyl myristate. The ointment was quite stable for at least 56 days at room temperature. An aminophylline ointment prepared in the same way showed less absorption and the change in appearance started after 1 week at room temperature. The serum levels of theophylline in the rats applied with the new theophylline ointment reached 10μg/mL after 2 h and a maximum level of 20μg/mL after 6 h. There was no apparent time lag in the absorption. These results suggest that a transdermal therapeutic system for the delivery of theophylline can be useful. even in the case of asthma attack.
- 日本医療薬学会の論文
- 1999-06-10
著者
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ARAKAWA Yoshihiro
Department of Aeronautics and Astronautics, The University of Tokyo
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Tsuchiya Masao
Department of Cardiol, Jichi Medical School
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Arakawa Y
Department Of Pharmacy Branch Hospital University Of Tokyo
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Kizu J
Department Of Practical Pharmacy Kyoritsu University Of Pharmacy
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Kizu J
Kyoritsu Univ. Pharmacy Tokyo Jpn
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Kizu Junko
Department Of Practical Pharmacy Keio University Faculty Of Pharmacy
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Kizu Junko
Department Of Pharmacy Branch Hospital Faculty Of Medicine University Of Tokyo
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Tsuchiya Masao
Department Of Cardiology And Medicine Jichi Medical School
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Tsuchiya Masao
Department Of Pharmacy Branch Hospital University Of Tokyo
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Arakawa Yoshihiro
Department Of Aeronautics And Astronautics University Of Tokyo
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YASUNO Nobuhiro
Department of Pharmacy, Branch Hospital, Faculty of Medicine, University of Tokyo
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YAZAWA MIDORI
Department of Pharmacy, Branch Hospital, Faculty of Medicine, Tokyo University
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Yasuno Nobuhiro
Department Of Pharmacy Branch Hospital University Of Tokyo
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Yazawa Midori
Department Of Pharmacy Branch Hospital Faculty Of Medicine Tokyo University
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Tuchiya Masao
Division Of Cardiology Jichi Medical School
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Arakawa Yoshihiro
Department Of Aeronautics And Astronautics The University Of Tokyo
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