Pathophysiological Significance of T-type Calcium Channels: Expression of T-type Ca2+ Channels in Fetal and Diseased Heart
スポンサーリンク
概要
- 論文の詳細を見る
Re-expression of fetal genes has been considered to underlie ionic remodeling in diseased heart. T-type Ca2+ channels have been reported to be functionally expressed in embryonic hearts. In this review, we summarize developmental changes of T-type Ca2+ channels in mouse ventricles from 9.5 days postcoitum (dpc) to adulthood, using patch clamp and quantitative PCR. In addition, we introduced T-type Ca2+ channel expression in hypertrophied ventricles caused by myocardial infarction (MI) and aortic banding (AOB). Substantial T-type Ca2+ channel current was recorded at both 9.5 and 18 dpc. The currents were inhibited by Ni2+ at low concentrations. The current was not detectable in the adult stage. Cav3.2 (α1H) mRNA is expressed dominantly at both 9.5 and 18 dpc. Cav3.1 (α1G) increases from 9.5 to 18 dpc, but remains at low level compared with Cav3.2. In contrast, Cav3.1 is greater than Cav3.2 at the adult stage. In MI, Cav3.1 mRNA correlates negatively with brain natriuretic peptide (BNP) mRNA, whereas Cav3.2 mRNA correlates positively with BNP mRNA. In AOB, these correlations are weak. We also analyzed the neuron-restrictive silencer factor (NRSF) in these hearts because it is the suppressor of transcription of the fetal cardiac gene program. The negative correlation between NRSF and BNP was stronger in MI than in AOB. Our findings show that Cav3.2 underlies the functional T-type Ca2+ channel in embryonic heart and suggest that NRSF may regulate Cav3.2 expression in diseased hearts.
- 社団法人 日本薬理学会の論文
著者
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Kodama Itsuo
Department of Cardiovascular Research, Research Institute of Environmental Medicine, Nagoya Universi
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YASUI Kenji
Department of Bioinformation Analysis, Research Institute of Environmental Medicine, Nagoya Universi
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Honjo Haruo
Department Of Cardiovascular Research Research Institute Of Environmental Medicine Nagoya University
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Kamiya Kaichiro
Department Of Humoral Regulation The Research Institute Of Environmental Medicine Nagoya University
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Lee Jong-kook
Department Of Cardiovascular Research Research Institute Of Environmental Medicine Nagoya University
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Yasui Kenji
Department Of Bioinformation Analysis Research Institute Of Environmental Medicine Nagoya University
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Takemura Haruki
Division Of Cardiovascular Research Reseearch Institute Of Environmental Medicine Nagoya University
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Horiba Mitsuru
Department of Bio-information Analysis, Research Institute of Environmental Medicine
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Shimizu Atsuya
Departments of Cardiovascular Research, Nagoya University
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Opthof Tobias
Experimental Cardiology Group, Center for Heart Failure Research, Academic Medical Center, The Nethe
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Honjo Haruo
Department Of Applied Physics Faculty Of Engineering
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Kanou Y
Division Of Molecular And Cellular Adaptation Research Institute Of Environmental Medicine Nagoya Un
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Kanou Yasuhiko
Department Of Genetics Research Institute Of Environmental Medicine Nagoya University
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NIWA Noriko
Department of Circulation, Research Institute of Environmental Medicine, Nagoya University
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TAKEMURA Haruki
Department of Cardio-Thoracic Surgery, Nagoya University Graduate School of Medicine
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MUTO Takao
Department of Circulation, Research Institute of Environmental Medicine, Nagoya University
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Niwa Noriko
Department Of Circulation Research Institute Of Environmental Medicine Nagoya University
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Opthof Tobias
Experimental And Molecular Cardiology Groups Academic Medical Center
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Kamiya Kaichiro
Department Of Cardiovascular Research Research Institute Of Environmental Medicine Nagoya University
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Lee Jong-kook
Department Of Cardiovascular Research R.i.e.m. Nagoya University
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Kodama Itsuo
Department Of Cardiovascular Research R.i.e.m. Nagoya University
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Hibino Takenori
Department Of Circulation Research Institute Of Environmental Medicine Nagoya University
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Shimizu Atsuya
Department Of Humoral Regulation Research Institute Of Environmental Medicine Nagoya University
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Yasui Kenji
Department Of Applied Chemistry Tokyo Metropolitan University
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