Apoptotic Cell Death in Arrhythmogenic Right Ventricular Cardiomyopathy : A Comparative Study with Idiopathic Sustained Ventricular Tachycardia

スポンサーリンク

概要

• 論文の詳細を見る

• Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a specific heart muscle disease of unknown etiology characterized by fatty and fibrofatty replacement of the right ventricular myocardium. It often manifests life-threatened ventricular arrhythmias. Previous studies have hypothesized that myocyte apoptosis contributes to the myocyte cell loss and fatty change in ARVC and may be induced by recurrent ventricular tachycardia (VT). We examined whether these progressive pathological changes result from apoptotic cell death in both autopsied and biopsied right ventricular myocardium from 35 patients with ARVC by using in situ terminal deoxynucleotidyl transferase assay (TUNEL) and agarose gel electrophoresis. We also studied the biopsied myocardium from 30 patients with idiopathic sustained VT whose origin was the outflow tract of the right ventricle. TUNEL-positive cells indicating DNA fragments were observed in some cardiomyocytes and fibroblasts in ARVC, but the numbers of TUNEL-positive myocytes were very low in idiopathic VT. DNA laddering was confirmed in two autopsied cases in ARVC, but not in a non-cardiac case who died. These results suggest that at least some cardiomyocytes and fibroblasts are subjected to apoptosis in ARVC, leading to the loss of myocardium with characteristic pathological changes and subsequently progressive cardiomyopathy. Furthermore, the apoptotic process may not result from myocardial ischemia due to repetitive VT.

• Japanese Heart Journal Associationの論文

著者

• Nishikawa Toshio

  Department of Surgical Pathology, Tokyo Womens Medical University

• Hiroe Michiaki

  国立国際医療センター研究所 遺伝子診断治療開発研究部

• Nagata Makoto

  the Department of Geriatrics, Tokyo Womens Medical University

• Hiroe Michiaki

  2nd Department of Medicine, Tokyo Medical and Dental University

• Ishiyama Shigeru

  Department of 2 Pathology, Tokyo Womens Medical University

• Sakomura Yasunari

  Cardiology, Tokyo Womens Medical University

• Kasanuki Hiroshi

  Cardiology, Tokyo Womens Medical University

• Toyosaki Tetsuya

  Division of Pathology, Institute of Pulmonary Cancer Research, Chiba University School of Medicine

• Marumo Fumiaki

  2nd Department of Medicine, Tokyo Medical and Dental University

• Marumo Fumiaki

  2nd Department Of Internal Medicine Tokyo Medical And Dental University(tmdu)

• Nishikawa Toshio

  Departmen Of Surgical Pathology Tokyo Women's Medical College

• Kasanuki Hiroshi

  Cardiology Tokyo Women's Medical College

• Hiroe Michiaki

  2nd Department Of Internal Medicine Tokyo Medical And Dental University(tmdu)

• Sakomura Yasunari

  Cardiology, Tokyo Women's Medical University

• Nagata Makoto

  the Department of Geriatrics, Tokyo Women's Medical University

• Ishiyama Shigeru

  Department of 2 Pathology, Tokyo Women's Medical University

関連論文

• PJ-189 Eicosapentaenoic Acid Attenuates Arterial Medial Calcification in the Vascular Calcification Model Rats through the Supression of Matrix Metalloproteinases(PJ032,Peripheral Circulation/Vascular Disease (Pathophysiology, Basic) 1 (H),Poster Session
• Insulinoma with Six Islet Cell Tumors Associated with Severe Hypoglycemia
• Enhanced Expression of the S100A8/A9 Complex in Acute Myocardial Infarction Patients
• OE-380 Signal-Averaged Vector-Projected 187-channel High-Resolution Electrocardiogram Can Evaluate Recovery-Time and Tpeak-end Dispersion(ECG/Body surface potential mapping/Holter-1, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
• PJ-746 Clinical Characteristics in Acute Heart Failure Syndromes Patients with and without Atrial Fibrillation : A Preliminary Report from ATTEND Registry(PJ125,Preventive Medicine/Epidemiology/Education 3 (H),Poster Session (Japanese),The 73rd Annual Sci
• PJ-331 Day and Time of Admission, Clinical Characteristics, and Outcomes in Acute Heart Failure Syndromes : A Report from the ATTEND Registry(PJ056,Preventive Medicine/Epidemiology/Education 2 (H),Poster Session (Japanese),The 73rd Annual Scientific Meeti
• 2 Refractory VT/VF, Prospective Evaluation to Differentiate Lidocaine Efficacy from Nifekalant : RELIEF Study(Late Breaking Clinical Trials I,The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
• Multicenter Prospective Nonrandomized Study of Long-Term Antiarrhythmic Drug Therapy in Patients With Tachyarrhythmias : Japanese Antiarrhythmics Long-Term Study-2 (JALT-2 Study)
• FRS-112 Influence of the Early Ticlopidine Discontinuation on Clinical Outcomes following Sirolimmus-Eluting Stent Implantation(FRS23,Clinical Evidence of DES Era (1) (IHD),Featured Research Session (English),The 73rd Annual Scientific Meeting of The Japa
• FRS-111 Contemporary Practice Use of Sirolimus-Eluting Stents in Hemodialysis Patients : The Results from HIJ-DES Registry(FRS23,Clinical Evidence of DES Era (1) (IHD),Featured Research Session (English),The 73rd Annual Scientific Meeting of The Japanese
• 2 Prognostic Factors in Patients with Coronary Artery Disease Treated with Sirolimus-eluting Stent : The HIJ-DES registry(Current Status and Future Perspective of Drug-Eluting Stents,Plenary Session 1 (PL-1) (A),The 73rd Annual Scientific Meeting of The J
• Apoptotic Cell Death in Arrhythmogenic Right Ventricular Cardiomyopathy : A Comparative Study with Idiopathic Sustained Ventricular Tachycardia
• PJ-348 Utility of ECG-gated MDCT to Differentiate Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) from Ventricular Tachyarrhythmia(PJ059,CT/MRI (Myocardium) 1 (I),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulat
• Communication Scheme for a Highly Collision-Resistive RFID System( Analog Circuit Techniques and Related Topics)
• PJ-200 Depression Persists in Patients with Implantable Cardioverter Defibrillator in Long Term(PJ034,Stress-psychosomatic Medicine (H),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
• PJ-064 Evaluation of Myocardial Damage by Magnetic Resonance Imaging in Patients with Duchenne Muscular Dystrophy(PJ011,CT/MRI (Myocardium) 4 (I),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
• OJ-209 Localization of Mitral Valve Prolapse Affects the Geometry of the Mitral Annulus(OJ35,Valvular Heart Disease/Pericarditis/Cardiac Tumor 1 (M),Oral Presentation (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
• 6 Prevalence and Characteristics of Depression in Cardiovascular Patients in Japan(Is Stress a Risk of Cardiovascular Disease?,Symposium 22 (SY-22) (I),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
• PE-359 A New Index of Diastolic Dysfunction in Mitral Regurgitation(PE060,Valvular Heart Disease (M),Poster Session (English),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
• Successful treatment of a patient with severe pulmonary hypertension due to perivalvular leakage at aortic and mitral positions after aortic and mitral valve replacement
• Fibroblast sheets co-cultured with endothelial progenitor cells improve cardiac function of infarcted hearts
• PJ-162 Significant Effects of EPA on Aortic Medial Calcification in the Vascular Calcification Model Rats(Peripheral circulation/Vascular disease(06)(H),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
• PE-317 Spectral Map of Atrial Fibrillation and Atrial flutter by a 187-channel Signal-averaged Vector projected ECG compared with 64 Channel Magnetocardiogram(ECG/Body surface potential mapping/Holter(04)(A),Poster Session(English),The 72nd Annual Scienti
• PE-316 Development of 187-Channel Signal-Averaged Vector-Projected Electrocardiogram for the Evaluation of the Spatial Distribution of Repolarization Heterogenelty(ECG/Body surface potential mapping/Holter(04)(A),Poster Session(English),The 72nd Annual Sc
• Factors Governing Re-Infarction in Patients with Myocardial Infarction in Japan
• Follow-up of 2, 733 Japanese Patients with Myocardial Infarction
• Percutaneous Transluminal Coronary Angioplasty for Postoperative Left Coronary Artery Stenosis Following Surgical Reconstruction of Congenital Atresia of the Left Main Coronary Artery
• Management of late atrial tachyarrhythmia long after Fontan operation
• PJ-745 How do You Act in Case of Acute Chest Sipmptoms : Questionare for Patients with Coronary Risk Factors(PJ125,Preventive Medicine/Epidemiology/Education 3 (H),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulation So
• PE-201 Vector-projected 187-channel Electrocardiogram can Evaluate an Alternance of T-wave Current Density and Disptribution(PE034,ECG/Body Surface Potential Mapping/Holter (A),Poster Session (English),The 73rd Annual Scientific Meeting of The Japanese Ci
• PE-194 The Initial Experience of Transvenous Leads Extraction Assisted by the Excimer Laser System(PE033,Arrhythmia, Others (Clinical/Diagnosis/Treatment) 3 (A),Poster Session (English),The 73rd Annual Scientific Meeting of The Japanese Circulation Societ
• PE-048 Insulin Treatments Overweigh the Beneficial Effect of Sirolimus Eluting Stent(PE008,Coronary Revascularization, PCI (DES) 1 (IHD),Poster Session (English),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
• 2 Management of "Anticipated" Admissions in Adult Congenital Heart Disease Clinic(Patient Menagement System for Adult Congenital Heart Disease,Symposium 19 (SY-19) (M),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
• Efficacy and Safety of Intravenous Amiodarone Infusion in Japanese Patients with Hemodynamically Compromised Ventricular Tachycardia or Ventricular Fibrillation
• Stage IVB uterine endometrial cancer successfully salvaged by chemoradiotherapy and surgery
• Peroxisome Proliferator-Activated Receptors (PPARs) and PPARγ Coactivator-1 Are Expressed Synergetically in Patients with Dilated Cardiomyopathy and Severe Left Ventricular Failure
• Regional cardiac sympathetic reinnervation in transplanted human hearts detected by ^I-MIBG SPECT imaging
• Clinical Characteristics and Outcome of Hospitalized Patients With Congestive Heart Failure : Results of the HIJC-HF Registry
• Primary Percutaneous Coronary Intervention vs Conservative Treatment for Acute ST Elevation Myocardial Infarction : Short- and Long-Term Follow-up According to Disease Severity
• Histopathologic aspects of endomyocardial biopsy in pediatric patients with idiopathic ventricular tachycardia
• Mycardial Mast Cells Is Involved in Cardiac Remodeling Processof Myocarditis : Immunohistochemical Analysis in RV Endomyocardial Biopsy Specimens
• Expression of Urotensin-II in Dilated Cardiomyopathy with End-Stage Congestive Heart Failure Is Reduced after Left Ventricular Assist Device Support
• Expression of peroxisome proliferator-activated receptor gamma in patients of dilated cardiomyopathy with severe left heart failure
• Primary Cardiac Angiosarcoma of the Right Atrium Undiagnosed by Transvenous Endocardial Tumor Biopsy
• PJ-227 Osteogenic Mechanism Plays a Significant Role in Aortic Medial Calcification(Atherosclerosis, basic(06)(IHD),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
• Sequential Bypass Using the Right Gastroepiploic Artery for Coronary Artery Bypass Grafting
• Acute Occlusion of Coronary Artery Bypass Graft With Nonionic Contrast Medium
• A HISTOPATHOLOGICAL COMPARATIVE STUDY OF DISPROPORTIONATE VENTRICULAR SEPTAL HYPERTROPHY ASSOCIATED WITH CONGENITAL HEART DISEASES AND HYPERTROPHIC CARDIOMYOPATHY : Cardiomyopathy (I) : 46th Annual Scientific Meeting, Japanese Circulation Society
• 2 How to Promote Coexistence of Child Raising and Medical Research for Female Cardiologists(How to Avoid Women Cardiologists from Quitting Their Job,Symposium 20 (SY-20) (A),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
• Airway Hyperresponsiveness in Patients With Coronary Spastic Angina : Relationship Between Coronary Spasticity and Airway Responsiveness
• Synergistic upregulation of ABCA1 mRNA by Angiotensin II and oxidized LDL in human peripheral blood monocyte from normocholesterolemic healthy volunteers
• Pre-hospital treatment of patients with acute coronary syndrome during transportation by "mobile-CCU"
• Ectopic Adrenocorticotropin Syndrome Exhibiting Paradoxical Adrenocorticotropin Responsiveness to Gonadotropin - Releasing Hormone
• 0585 SUDDEN PROLONGATION OF FLUTTER CYCLE LENGTH DURING LINEAR CATHETER ABLATION AT INFERIOR VENA CAVA AND TRICUSPID ANNULUS IN COMMON ATRIAL FLUTTER : THE MEANING AND CLINICAL RELEVANCE
• 0114 MORPHOLOGY OF SURFACE ELECTROCARDIOGRAM OF ORTHODROMIC AND ANTIDROMIC COMMON ATRIAL FLUTTER : PREDICTIVITY BY PACING FROM SEPTAL AND LATERAL SIDE OF LINEAR ABLATION LINE AT IVC-TA ISTHMUS
• P660 PREDICTIVE FACTORS OF SUCCESSFUL RADIOFREQUENCY CATHETER ABLATION OF VENTRICULAR TACHYCARDIA POST MYOCARDIAL INFARCTION : SIGNIFICANCE OF EXTENT OF COMMON PATHWAY IN REENTRY CIRCUIT
• P655 ATRIOVENTRICULAR NODE RADIOFREQUENCY ABLATION IN PATIENTS WITH UNCONTROLLABLE SUPRAVENTRICULAR TACHYARRHYTHMIAS : SAFETY AND LONG TERM EFFICACY
• -P469- Role of Endogenous Endothelin-1 in Stretch-Induced Cardiomyocyte Hypertrophy in Vitro(PROCEEDINGS OF THE 59th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY)
• -P249- SAFETY AND EFFICACY OF CATHETER ABLATION WITH HIGH ENERGY, LONG DURATION APPLICATION OF RADIOFREQUENCY CURRENT(PROCEEDINGS OF THE 59th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY)
• -P235- ADENOSINE-SENSITIVE ATRIAL TACHYCARDIA DUE TO INTRAATRIAL REENTRY INVOLVING ATRIOVENTRICULAR NODE(PROCEEDINGS OF THE 59th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY)
• IS081 A Novel Parameter for Physiological Assessment of Coronary Stenosis Obtained by Intracoronary Pressure Measurements : Epicardial Resistance Ratio(ER)
• Profiles of Aprindine, Cibenzoline, Pilsicainide and Pirmenol in the Framework of the Sicilian Gambit
• IS090 Persistent Infection of Helicobacter Pylori Is Associated With Impaired Endothelium-dependent Vasomotor Function in Angiographically Normal Coronary Arteries
• Prevention against Sudden Cardiac Death in Patients with Highly-risked Cardiac Disease : Tokyo Coronary Care Home Defibrillation Program(Emergency Care 1 (H), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
• PE-152 Signal-Averaged Vector-Projected 187-channel High-Resolution Electrocardiogram Can Evaluate Space Distribution of High-Frequency Low-Amplitude Potential(ECG/Body surface potential mapping/Holter-4, The 71st Annual Scientific Meeting of the Japanese
• St. Jude Medical Prosthetic Aortic Valve Malfunction Due to Pannus Formation
• THE CHARACTERISTICS OF I-123 MIBG MYOCARDIAL IMAGES IN PATIENTS WITH VASOSPASTIC ANGINA : IN COMPARISON WITH CHEST PAIN SYNDROME AND SYNDROME X
• PJ-735 The Same Mutations in the Cardiac Troponin T Gene Show Various Prognoses in Japanese Patients with Hypertrophic Cardiomyopathy(Cardiac hypertrophy, basic/clinical-4 (M) PJ125,Poster Session (Japanese),The 70th Anniversary Annual Scientific Meeting
• Genotype and Phenotype of Cardiovascular Diseases (del22q11.2, Williams and Brugada syndromes)
• IS052 A mitochondrial DNA is responsible for the pathogenesis of congenital long QT syndrome
• IS091 Electrophysiological properties of the mutant HERG channel (G601S) expressed in mammalian cells
• IS022 Apoptotic cell death starts at longitudinally oriented smooth muscle in the inner layer of the ductus arteriosus after birth
• 0720 Genetic analysis of familial long QT Syndrome : Missense mutation in HERG in LQT2 family
• CHANGE IN α AND β MYOSIN HEAVY CHAIN IN COARCTATED RAT HEART : Cardiomyopathy (II) : PROCEEDINGS OF THE 50th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
• Outcome of Breast-Conserving Therapy in the Tokyo Women's Medical University Breast Cancer Society Experience
• New Prognostic Factors Associated with Long-term Survival in Node-Negative Breast Cancer Patients
• Congestive Heart Failure After Peripheral Blood Stem Cell Transplantation : Role of Cytokines
• CHARACTERISTICS OF POWER SPECTRA IN PATIENTS WITH OLD MYOCARDIAL INFARCTION : Ventricular Function : 53 Annual Scientific Meeting, Japanese Circulation Society
• -54-A LONG TERM FOLLOW-UP OF CLINICAL FEATURE AND ARRHYTHMOGENICITY IN PATIENTS WITH ARRHYTHMOGENIC RIGHT VENTRICULAR DYSPLASIA : Arrhythmias : FREE COMMUNICATIONS(I) : PROCEEDINGS OF THE 53th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
• Vasospastic Angina in a Patient With Fabry's Disease who Showed Normal Coronary Angiographic Findings
• Immunohistochemical Analysis of Growth Factors in Cyanotic Nephropathy
• 1 Pathomorphological/histopathological Assessment of Cardiomyopathies(Morphology Revisited: Roles for Morphology in Cardiovascular Research and Medicine,Meet the Expert 3 (ME3) (M),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation
• Teratogenic Effect of Tedral (Theophylline, Ephedrine, and Phenobarbital) on Cardiac Development in Chick Embryos
• 0884 Acetylcholine induced vasoconstriction in epicandial artery and microcirculation, and the relation with pathological change in dilated cardiomyopathy
• UNFILTERED UNIPOLAR ELECTROGRAM PREDICTIVE OF SUCCESSFUL CATHETER ABLATION OF ACCESSORY PATHWAY
• EVALUATION OF ELECTROGRAM PARAMETERS AT SLOW PATHWAY SUCCESSFUL ABLATION SITE IN ATRIOVENTRICULAR NODAL REENTRANT TACHYCARDIA
• EFFICACY AND DIFFICULTIES IN RADIOFREQUENCY CATHETER ABLATION OF THE RIGHT-SIDED ATRIOVENTRICULAR ACCESSORY PATHWAY
• -P11-RELATIONSHIP BETWEEN INTRACARDIAC DELAYED POTENTIAL AND INDUCIBILITY OF VENTRICULAR TACHYCARDIA IN CANINE MODEL OF MYOCARDIAL INFARCTION : Electrophysiology : FREE COMMUNICATIONS(III) : PROCEEDINGS OF THE 53th ANNUAL SCIENTIFIC MEETING OF THE JAPANES
• -0860- COMPARATIVE STUDY OF ECG CRITERIA FOR FURTHER LOCALIZATION OF THE POSTEROSEPTAL ACCESSORY PATHWAY IN WOLFF-PARKINSON-WHITE SYNDROME(PROCEEDINGS OF THE 59th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY)
• -0493- FEASIBILITY OF TRANSVERSE LINEAR ABLATION OF INFERIOR VENA CAVA-TRICUSPID VALVE ISTHMUS IN COMMON ATRIAL FLUTTER(PROCEEDINGS OF THE 59th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY)
• STUDY ON THE MAXIMAL EXERCISE IN PATIENTS WITH ANGINA PECTORIS : HEMODYNAMIC CHANGES AND DRUGS AFFECTING THE INCIDENCE OF ANGINA PECTORIS
• HEMODYNAMICS OF MITRAL VALVE ORIFICE : CONSIDERATION OF CONTRACTED STREAM AND THE EFFECT OF β-STIMULATOR
• Primary Leiomyosarcoma of the Breast Treated by Partial Resection of the Breast Including Nipple and Areola : Report of a Case
• DEFFERENCES IN ELECTROGRAM AT SUCCESSFUL SITE IN CATHETER ABLATION OF ACCESSORY PATHWAY ACCARDING TO ITS LOCATION
• COMPARISON OF THE SAFETY AND EFFICACY BETWEEN DERECT CURRENT AND RADIOFREQUENCY ENERGY IN CATHETER ABLATION OF ACCESSORY ATRIOVENTRICULAR PATHWAYS OF THE WOLFF-PARKINSON-WHITE SYNDROME
• Inhibition of mTOR by temsirolimus contributes to prolonged survival of mice with pleural dissemination of non-small-cell lung cancer cells
• Adult onset cardiac dilatation in a transgenic mouse line with Galβ1,3GalNAc α2,3-sialyltransferase II (ST3Gal-II) transgenes: a new model for dilated cardiomyopathy
• Comparison of the Clinical Presentation, Treatment, and Outcome of Fulminant and Acute Myocarditis in Children
• Team-Based Learning, a Learning Strategy for Clinical Reasoning, in Students with Problem-Based Learning Tutorial Experiences
• Evaluation of SRAM-Core Susceptibility against Power Supply Voltage Variation

もっと見る 閉じる

スポンサーリンク