Multicenter Prospective Nonrandomized Study of Long-Term Antiarrhythmic Drug Therapy in Patients With Tachyarrhythmias : Japanese Antiarrhythmics Long-Term Study-2 (JALT-2 Study)

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概要

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• Based on the results of the Cardiac Arrhythmia Suppression Trial (CAST), strategies for the treatment of tachyarrhythmias have changed rapidly. The Japanese Antiarrhythmics Long-Term (JALT) study was planned to investigate the present methods for choosing antiarrhythmic drugs, and the effects on long-term prognosis in patients with tachyarrhythmias in Japan. Following a 6-month preliminary study (JALT-1), there was a multicenter nonrandomized prospective study (JALT-2), with a 2-year follow-up, of patients with paroxysmal atrial fibrillation (PAF), sustanined ventricular tachycardia (SVT) and nonsustained VT (NSVT). Four hundred fiftyfive patients were registered, and 361 of then (79%) were analyzed. Cerebral infarction occurred in 10 of 193 patients (5.2%) with PAF. Transition to chronic AF was observed in 21 patients (10.9%), but in none of the patients receiving Ca antagonist therapy. Twenty-five patients died: 5 deaths were arrhythmic, 10 were because of pump failure, and 9 were noncardiac. The most significant difference in drug selection between JALT-1 and JALT-2 was the increase in the use of slow kinetic Na channel blockers for PAF and the decrease in the use of the same agents for VT in the JALT-2 study. A marked change of therapeutic strategy occurred in JALT-2 compared with JALT-1. Most patients with a poor prognosis had underlying heart disases and heart failure, but the per annum rate of death by arrhythmia and pump failure in JALT-2 was less than that in JALT-1.

• 社団法人日本循環器学会の論文
• 2001-03-20

著者

• 小川 聡

  国際医療福祉大学三田病院

• 小川 聡

  国際医療福祉大 三田病院

• 小川 智

  岩手大学工学部応用化学科

• Ogawa Satoshi

  心臓血管研究所

• Ohe Tohru

  Cardiovascular Medicine, Okayama University

• Ohara Takahiro

  国立循環器病センター 心臓血管内科

• Hayakawa Hirokazu

  The First Department of Internal Medicine, Nippon Medical School

• Ohe Tohru

  Japanese Lqts Multicenter Registry By The Minister Of Health Lobour And Welfare National Cardiovascu

• Katoh Takao

  The First Department of Internal Medicine, Nippon Medical School, Tokyo Japan Organizing Members of

• Iinuma Hiroyuki

  Executive Committee for JALT-2 Study Group

• Inoue Hiroshi

  Executive Committee for JALT-2 Study Group

• Ohe Tohru

  Executive Committee for JALT-2 Study Group

• Ogawa Satoshi

  Executive Committee for JALT-2 Study Group

• Kasanuki Hiroshi

  Executive Committee for JALT-2 Study Group

• Tanabe Teruhisa

  Executive Committee for JALT-2 Study Group

• Hayakawa Hirokazu

  The First Department Of Medicine Nippon Medical School

• Hayakawa Hirokazu

  The First Department Of Internal Medicine Nippon Medical School

• HAYAKAWA Hirokazu

  Yotsuya Medical Cube

• HASHIMOTO Katsuji

  Osaka National Hospital

• Konagai Hideo

  Department Of Cardiology Musashino Red Cross Hospital

• Kikuchi Hiroshi

  Saiseikai Kumamoto Hospital

• Kasanuki Hiroshi

  Department Of Cardiovascular Medicine Tokyo Women's Medical University

• Ohe Toru

  The Sakakibara Heart institute of Okayama

• Katoh Takao

  The First Department Of Internal Medicine Nippon Medical School

• Iinuma Hiroyuki

  Second Department Of Internal Medicine University Of Toyama

• Hoshiyama Kouki

  Cardiology Division Department Of Medicine Keio University School Of Medicine

• Ohashi Hiroshi

  Department Of Cardiovascular Surgery Tokyo Women's Medical University

• Tanizaki Kohei

  Department Of Cardiology The Heart Institute Of Japan Tokyo Women's Medical University

• Kasanuki Hiroshi

  Dept. Of Clinical Pathology Iwate Medical University & The Heart Institute Of Japan

• Kasanuki Hiroshi

  Departments Of Internal Medicine

• Ohe Tohru

  Department Of Cardiovascular Surgery And Cardiology

• Kasanuki Hiroshi

  Cardiology Tokyo Women's Medical College

• Ogawa Satoshi

  Department Of Chemical Engineering Faculty Of Engineering Iwate University

• Ohe Toru

  Cardiovascular Medicine Okayama University

• Ohe Tohru

  Division Of Cardiology Department Of Medicine National Cardiovascular Center

• Ohe Tohru

  Department Of Cardiovascular Surgery National Cardiovascular Center

• Ohe Toru

  Cardiac Division Department Of Medicine National Cardiovascular Center Hospital

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