Tea Catechin Consumption Reduces Circulating Oxidized Low-Density Lipoprotein
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概要
- 論文の詳細を見る
It has been reported that green tea consumption reduces the risk of coronary artery disease and cardiac events. Catechin is a major constituent of Japanese green tea and an antioxidant. Lipids and oxidization of low-density lipoprotein cholesterol (LDL-C) play important roles in atherosclerosis. Therefore, we evaluated the effect of catechin intake on the lipid profile and plasma oxidized LDL. The study population consisted of 40 healthy adult volunteers (10 men, 30 women). Catechin was extracted from green tea leaves. The subjects were randomly divided into two groups, a catechin group (n = 29) and a control group (n = 11). In the catechin group, catechin (500 mg: equivalent to 6 or 7 cups of green tea) was administered orally. Venous blood samples were obtained before eating a meal at the start and after 4 weeks without any lifestyle modification. Plasma oxidized LDL assay was performed with a sandwich-type enzyme immunoassay using anti-oxidized phosphatidylcholine monoclonal antibody. The baseline lipid profiles and tea consumptions were similar between the two groups. Plasma oxidized LDL was significantly decreased after catechin administration (from 9.56 ± 9.2 to 7.76 ± 7.7 U/mL, P = 0.005), while plasma LDL-C, triglyceride, and HDL-C concentrations did not change. Catechin decreased the plasma oxidized LDL concentration without significant change in plasma LDL concentration. The mechanism of the beneficial effects of green tea on coronary artery disease might result from a decrease in plasma oxidized LDL.
著者
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Yamamoto Masanori
Department of Cardiovascular center, Chiba-Hokusoh Hospital, Nippon Medical School
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Tajika Kenichiro
Department of Internal Medicine, Division of Cardiology, Nippon Medical School
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Takano Masamichi
Department of Internal Medicine, Chiba-Hokusoh Hospital, Nippon Medical School
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Inami Shigenobu
Department Of Cardiology Tohsei National Hospital
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Sano Junko
Department of internal medicine, Nippon Medical School Chiba Hokusoh Hospital
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Ohno Norihiko
Department Of Cardilogy Nippon Medical School
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Mizuno Kyoichi
Department Of 1st Internal Medicine Nippon Medical School
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Yodogawa Kenji
Department Of Cardiology Tohsei National Hospital
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Ibuki Chikao
Departent Of Cardiology Chiba-hokuso Hospital Nippon Medical School
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Seino Yoshihiko
Department Of Cardiology Chiba-hokuso Hospital
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Yokoyama Shinya
Department Of Cardiovascular Surgery Kinki University Graduate School Of Medicine Nara Hospital
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Murakami Daisuke
Department of Cardiology, Cardiovascular Center, Nippon Medical School Chiba-Hokusoh Hospital
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Ohba Takayoshi
Department of Cardiology, Cardiovascular Center, Nippon Medical School Chiba-Hokusoh Hospital
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Ohba Takayoshi
Department of Internal Medicine, Chiba-Hokusoh Hospital, Nippon Medical School
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Yodogawa Kenji
Department of Internal Medicine, Chiba-Hokusoh Hospital, Nippon Medical School
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Sano Junko
Department of Internal Medicine, Chiba Hokusoh Hospital, Nippon Medical School
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Tajika Kenichiro
Department of Internal Medicine, Chiba-Hokusoh Hospital, Nippon Medical School
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Takano Masamichi
Department of Cardiology, Cardiovascular Center, Nippon Medical School Chiba-Hokusoh Hospital
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Ibuki Chikao
Department of Internal Medicine, Chiba-Hokusoh Hospital, Nippon Medical School
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Seino Yoshihiko
Department of Internal Medicine, Chiba-Hokusoh Hospital, Nippon Medical School
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