Effects of Statins on Circulating Oxidized Low-density Lipoprotein in Patients With Hypercholesterolemia
スポンサーリンク
概要
- 論文の詳細を見る
Recently, it has been reported that circulating oxidized low-density lipoprotein (Ox-LDL) might be a pivotal indicator for coronary artery disease and the severity of acute coronary syndromes. The purpose of this study was to investigate the effects of statins on Ox-LDL in patients with hypercholesterolemia. Sixteen patients with hypercholesterolemia were randomly assigned to 2 groups, one received 10 mg of pravastatin (n = 8) and the other received 20 mg of fluvastatin (n = 8). The plasma level of Ox-LDL was measured using a newly developed sandwich enzyme-linked immunosorbent assay (ELISA) method. There were no differences between the two groups in Ox-LDL, total cholesterol (TC), or LDL cholesterol (LDL-C) at the baseline. The reduction in Ox-LDL in the fluvastatin group was significantly higher than that in the pravastatin group (47.5% versus 25.2%, P = 0.033). The reductions in TC and LDL-C did not differ between the two groups. Conclusion: The present study has shown for the first time that the level of circulating Ox-LDL was significantly decreased by treatment with statins. In addition, the lowering effect of statins on the circulating Ox-LDL was independent of their lipid-lowering effect. Fluvastatin was more effective than pravastatin with regard to decreasing the circulating Ox-LDL.
著者
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Takano Masamichi
Department of Internal Medicine, Chiba-Hokusoh Hospital, Nippon Medical School
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Inami Shigenobu
Department Of Cardiology Tohsei National Hospital
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Okamatsu Kentaro
Department Of Internal Medicine Chiba-hokusoh Hospital Nippon Medical School
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Sano Junko
Department of internal medicine, Nippon Medical School Chiba Hokusoh Hospital
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Mizuno Kyoichi
Department Of 1st Internal Medicine Nippon Medical School
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Takagi Gen
Department Of 1st. Internal Medicine Nippon Medical School
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Sakai Shunta
Department Of Cardiology Nippon Medical School Chiba Hokusoh Hospital
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Okamatsu Kentaro
Department of Internal Medicine, Chiba Hokusoh Hospital, Nippon Medical School
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Sano Junko
Department of Internal Medicine, Chiba Hokusoh Hospital, Nippon Medical School
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Takano Masamichi
Department of Cardiology, Cardiovascular Center, Nippon Medical School Chiba-Hokusoh Hospital
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Takano Masamichi
Department of Internal Medicine, Chiba Hokusoh Hospital, Nippon Medical School
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Mizuno Kyoichi
Department of Internal Medicine, Chiba Hokusoh Hospital, Nippon Medical School
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