Long-Term Effect of Imidapril Hydrochloride Compared With Dilazep Hydrochloride Administration on Blood Pressure and Renal Function in Patients With Chronic Glomerulonephritis
スポンサーリンク
概要
- 論文の詳細を見る
The objective of the present study was to compare the effects of imidapril hydrochloride, an angiotensin converting enzyme inhibitor, and dilazep hydrochloride, an antiplatelet agent, on urinary protein excretion and renal function in patients with chronic glomerulonephritis. Imidapril (2.5 or 5 mg/day) or dilazep (300 or 450 mg/day) was administered for 3 years. Blood pressure, proteinuria, and renal function were measured before and during the treatment. In the group administered imidapril (n = 11), urinary protein decreased by approximately 50% (2.16 ± 1.57 versus 0.90 ± 0.53 g/g Cr, P < 0.01) and blood pressure by 14/10 mmHg (139.6 ± 17.4/93.6 ± 8.7 mmHg versus 122.7 ± 10.5/81.8 ± 9.9 mmHg, P < 0.01) and both remained at low levels during the three years of treatment. No correlation was observed between the extent of blood pressure reduction and changes in urinary protein. Serum creatinine concentrations did not change significantly (1.3 ± 0.3 versus 1.3 ± 0.3 mg/dL, NS). In the dilazep group (n = 12), there were no significant changes in blood pressure, urinary protein, or serum creatinine. These findings demonstrate that imidapril reduces proteinuria and contributes to preserve renal function, suggesting its usefulness in the treatment of patients with chronic glomerulonephritis.
- International Heart Journal刊行会の論文
著者
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Takahashi Masao
Department Of Cardiovascular Medicine Graduate School Of Medicine University Of Tokyo
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Suzuki Etsu
Department of Cardiovascular Medicine, University of Tokyo
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KAMIJO Atsuko
Department of Internal Medicine, St. Marianna University School of Medicine
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Nagata Daisuke
Department Of Cardiovascular Medicine Graduate School Of Medicine University Of Tokyo
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Hirata Yasunobu
Department Of Advanced Clinical Science And Therapeutics Cardiovascular Medicine Graduate School Of
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SATONAKA Hiroshi
Department of Internal Medicine, Graduate School of Medicine, the University of Tokyo
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Takeda Ryo
Department Of Chemistry Graduate School Of Science Osaka University
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Kimura Kenjiro
Department Of Biochemistry National Cerebral And Cardiovascular Center Research Institute
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Hayakawa Hiroshi
Departmennt Of Pediatrics Mejirodai Campus University Of Tokyo
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Oba Shigeyoshi
Department Of Internal Medicine Faculty Of Medicine University Of Tokyo
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YAMAMOTO Yuji
Department of Agricultural Chemistry, Faculty of Agriculture, Tokyo University of Agriculture
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Nishimatsu Hiroaki
Department of Internal Medicine, Graduate School of Medicine, University of Tokyo
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Takeda Ryo
Department of Internal Medicine, Graduate School of Medicine, University of Tokyo
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Suzuki Etsu
Department of Internal Medicine, Graduate School of Medicine, University of Tokyo
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Nagata Daisuke
Department of Internal Medicine, Graduate School of Medicine, University of Tokyo
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Satonaka Hiroshi
Department of Internal Medicine, Graduate School of Medicine, University of Tokyo
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Kamijo Atsuko
Department of Internal Medicine, Graduate School of Medicine, University of Tokyo
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Hirata Yasunobu
Department of Internal Medicine, Graduate School of Medicine, University of Tokyo
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