Diagnosis and Treatment of Endothelial Dysfunction in Cardiovascular Disease : A Review
スポンサーリンク
概要
- 論文の詳細を見る
Vascular endothelial dysfunction reflected by reduced nitric oxide (NO) availability is certainly the causative factor or promoting mechanism of arteriosclerosis. It is necessary to detect endothelial dysfunction at an early stage using appropriate methods, and to choose a treatment for the recovery of endothelial function. There are nonpharmacological and pharmacological therapies to attain endothelial repair. The former includes body weight reduction, aerobic exercise, and restriction of salt intake, while the latter includes the use of renin-angiotensin system inhibitors, calcium antagonists, some types of β blockers, statins, erythropoietin, tetrahydrobiopterin, and antioxidants. These therapies are intended to increase NO synthase activity and NO release, inhibit NO degradation, and enhance the activity of endothelial progenitor cells.
著者
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Nagata Daisuke
Department Of Cardiovascular Medicine Graduate School Of Medicine University Of Tokyo
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Suzuki Jun-ichi
Advanced Science Research Center Japan Atomic Energy Agency
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Hirata Yasunobu
Department Of Advanced Clinical Science And Therapeutics Cardiovascular Medicine Graduate School Of
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Suzuki Etsu
Institute Of Medical Science St. Marianna University School Of Medicine
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Nagai Ryozo
Department Cardiovascular Medicine The University Of Tokyo Hospital
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Nishimatsu Hiroaki
Departments of Urology, Graduate School of Medicine, The University of Tokyo
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Nishimatsu Hiroaki
Department of Internal Medicine, Graduate School of Medicine, University of Tokyo
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Nagata Daisuke
Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo
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