Usefulness of the Percentage of Plasma Lymphocytes as a Prognostic Marker in Patients With Congestive Heart Failure: Comparison With Brain Natriuretic Peptide:Comparison With Brain Natriuretic Peptide
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概要
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This prospective study was designed to evaluate the prognostic value of the percentage of plasma lymphocytes in patients with diastolic dysfunction as well as systolic dysfunction of the left ventricle. The subjects were 70 consecutive patients who were hospitalized in our institution from April 2001 to August 2002. Following the improvement of congestive heart failure, leukocyte differentiation and neurohumoral factors (plasma levels of atrial and brain natriuretic peptide, norepinephrine, epinephrine, and dopamine) were measured. During the follow-up period (17 ± 9 months), 18 patients experienced a cardiac event. In the univariate analysis, the percentage of plasma lymphocytes in the cardiac event group was significantly less than that in the noncardiac event group (24.7 ± 8.40 vs 33.3 ± 7.64%, P = 0.0006), and brain natriuretic peptide was significantly larger in the cardiac event group (402 ± 168 vs 153 ± 51 pg/mL, P = 0.04). However, in patients with preserved systolic function, there was a significant difference in the percentage of plasma lymphocytes between the cardiac and noncardiac event groups (21.7 ± 9.42 vs 34.2 ± 8.21%, P = 0.037), although no difference was observed in brain natriuretic peptide (133 ± 43 vs 125 ± 50 pg/mL, P = 0.87). Multivariate analysis showed the percentage of plasma lymphocytes was an independent predictor of a cardiac event. The percentage of plasma lymphocytes may be useful for predicting the course of patients with congestive heart failure based on diastolic dysfunction as well as systolic dysfunction.
- International Heart Journal刊行会の論文
著者
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Hadase Mitsuyoshi
Department Of Cardiology Kyoto First Red Cross Hospital
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Sugihara Hiroki
Department of Cardiology, Matsushita Memorial Hospital
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Kamitani Tadaaki
Department Of Cardiology Matsushita Memorial Hosipital
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Kawasaki Shingo
Department of Cardiology, Matsushita Memorial Hospital
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Sakatani Tomohiko
Department of Cardiology, Matsushita Memorial Hospital
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Kawasaki Tatsuya
Department Of Cardiology Matsushita Memorial Hosipital
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Sakatani Tomohiko
Department Of Cardiology Matsushita Memorial Hosipital
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Kawasaki Shingo
Department Of Cardiology Matsushita Memorial Hospital
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Sugihara Hiroki
Department Of Cardiology Kyoto Prefectural University Of Medicine
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Hadase Mitsuyoshi
Department of Cardiology, Matsushita Memorial Hospital
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