Gated Single-Photon Emission Computed Tomography Detects Subendocardial Ischemia in Hypertrophic Cardiomyopathy
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概要
- 論文の詳細を見る
Background Patients with hypertrophic cardiomyopathy (HCM) sometimes develop subendocardial ischemia (SEI) in the left ventricle (LV). In the present study it was examined whether volumetric variables obtained by gated single-photon emission computed tomography (SPECT) are useful in detecting exercise-induced SEI in patients with HCM. Methods and Results Exercise ^<99m>Tc-tetrofosmin myocardial scintigraphy was performed in 26 HCM patients having non-obstruction and mild hypertrophy with a ventricular septal thickness ≤20mm. SEI was quantified using software developed previously, and the results were correlated with volumetric variables obtained using Quantitative Gated SPECT software. Exercise-induced percentage change in LV end-systolic volume was higher in 9 HCM patients with SEI (25.8±3.1%) than in 17 patients without (10.0±2.5%, p=0.009), although the percentage change in LV end-diastolic volume was similar in the 2 groups. The receiver-operator characteristics curve of the percentage changes in LV end-systolic volume for the detection of SEI showed that the optimal cutoff was 17%. This cutoff point yielded a good diagnostic value for the presence of SEI with a sensitivity of 89%, specificity 82%, and likelihood ratio 5.04. Conclusions Gated SPECT technique is useful in detecting SEI during exercise in a select population of HCM patients.
- 社団法人日本循環器学会の論文
- 2007-01-20
著者
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Akakabe Yoshiki
Department of Cardiolgy, Kyoto Prefectural University of Medicine
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Sugihara H
Department Of Cardiology Matsushita Memorial Hosipital
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Kawasaki Tatsuya
Department of Cardiology, Matsushita Memorial Hospital, Japan
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Kamitani Tadaaki
Department of Cardiology, Matsushita Memorial Hospital, Japan
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Yamano Michiyo
Department of Cardiology, Matsushita Memorial Hospital
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Miki Shigeyuki
Department of Cardiology, Matsushita Memorial Hospital
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Kuribayashi Toshiro
Kuribayashi Clinic of Cardiology
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Sugihara Hiroki
Department of Cardiology, Matsushita Memorial Hospital
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Kamitani Tadaaki
Department Of Cardiology Matsushita Memorial Hosipital
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Kamide Takashi
Department Of Cardiovascular Medicine Kyoto Prefectural University Of Medicine
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Sugihara Hiroki
松下電器健康保険組合松下記念病院 循環器科
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SHIRAISHI Hirokazu
the Kyoto Prefectural Yosanoumi Hospital
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Kawasaki Tatsuya
Department Of Cardiology Matsushita Memorial Hosipital
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Kamide Takashi
Department Of Cardiology Matsushita Memorial Hospital
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Sugihara Hiroki
Department Of Cardiology Kyoto Prefectural University Of Medicine
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Miki Shigeyuki
Department Of Cardiology Matsushita Memorial Hosipital
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Yamano Michiyo
Department Of Cardiology Matsushita Memorial Hospital
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Akakabe Yoshiki
Department Of Cardiology Matsushita Memorial Hospital
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Akakabe Yoshiki
Department Of Cardiolgy Kyoto Prefectural University Of Medicine
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Shiraishi Hirokazu
京都府立与謝の海病院
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Hirasaki Satoshi
Department Of Cardioology Matsushita Memorial Hospital
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Kuribayashi Toshiro
Second Department Of Medicine Kyoto Prefectural University Of Medicine.
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Katahira Toshio
Kuribayashi Clinic Of Cardiology
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Kuribayashi Toshiro
The Second Dept. Of Anat. Kyoto Pref. Univ. Of Med
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Kuribayashi Toshiro
Department Of Anatomy Kyoto Prefectural University Of Medicine
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Kusaba Tetsuro
Division Of Cardiology And Nephrology Department Of Medicine Kyoto Prefectural University Of Medicin
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Sugihara Hiroki
The 2nd. Dept. Of Int. Med. Kyoto Pref. Univ. Of Med.
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