微粒子コーティング装置の開発とその評価

概要

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A new fluidized bed particle coating equipment has been developed by combining following unique features of two different processing equipments:1. A fluidized bed processor has ideal particle circulation movement and drying capability.2. A commuting mill has a good dispersing ability of agglomerated particles.Using this newly developed fluidized bed processor, we first carried out coating experiments of fine particles under various conditions, and particle size distribution and dissolution profile of coated particles were measured.Coated particles were compressed into tablets and the dissolution profile of each tablet was also studied.The above study showed that the newly developed fluidized bed could coat each particle with sharp particle size distribution but without agglomeration. And uniform film layer was obtained.Moreover, it is confirmed that coated particles can be compressed into tablets without being damaged.
社団法人粉体粉末冶金協会の論文
2005-04-15