Transcriptional Coactivator p300/CBP-Associated Factor and p300/CBP-Associated Factor Type B Are Required for Normal Estrogen Response of the Mouse Uterus
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概要
- 論文の詳細を見る
Mice with targeted gene disruption of one of the estrogen receptor coactivators, p300/CBP-associated factor (PCAF), and its counterpart, PCAF-B, were used to investigate the possible involvement of PCAF and PCAF-B in estrogen receptor-mediated actions in vivo. Among ovariectomized mice that were treated with estrogen, PCAF and PCAF/PCAF-B knockouts showed abnormal growth of the uterus compared with the wild type. The level of c-fos gene expression in the uterus was not induced by estrogen in the knockouts. These observations suggest that PCAF and PCAF-B are required for estrogen-dependent normal growth of the uterus via estrogen receptor-mediated transcriptional regulations.
- 2004-10-23
著者
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Yamada Kazuhiko
Division Of Applied Food Research National Institute Of Health And Nutrition
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Yamauchi Jun
Division Of Applied Food Research National Institute Of Health And Nutrition
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Esashi Takatoshi
Division Of Applied Food Research National Institute Of Health And Nutrition
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Yamada K
Division Of Applied Food Research National Institute Of Health And Nutrition
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INOUE Erina
Division of Applied Food Research, National Institute of Health and Nutrition
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HANAI Miho
Division of Applied Food Research, National Institute of Health and Nutrition
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Inoue Erina
Division Of Applied Food Research National Institute Of Health And Nutrition
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Hanai M
Division Of Applied Food Research National Institute Of Health And Nutrition
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Hanai Miho
Division Of Applied Food Research National Institute Of Health And Nutrition:(present Address)depart
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