Effect of Dietary Magnesium Level on Nephrocalcinosis and Growth in Rats
スポンサーリンク
概要
- 論文の詳細を見る
We studied the extent of kidney calcification by varying dietary levels of Mg, based on pathological examinations and calcium (Ca) and magnesium (Mg) balance tests. AIN-76 diets containing varying levels of Mg-0.3 (-M), 1.3 (1 /20M), 2.4 (1/10M), 9.2 (1/5M), 19 (control), 38 (2M), 102 (5M), and 187 (10M) mmol/kg diet-were fed to 3-week-old male Fischer-344 rats for 14 d. Although the magnitude of abnormality was highest in kidney of rats fed the M diet, the damage was normalized as the dietary level of Mg increased, with increasing serum Mg concentration and urinary excretion of Mg. We found almost no deposition of Ca in rats fed the 1OM diet. The mechanism by which the high dietary Mg induces these effects most likely involves a competition between Mg and Ca for reabsorption in proximal and/or distal tubules, since these diets increased the urinary excretion of Ca. However, these high Mg diets decreased food intake and body weight gain compared with the control diet, although these indices were not decreased in rats fed the 2M diet. The results suggest that a dietary magnesium level approximately twice the normal level effectively reduces kidney calcification while maintaining normal growth in rats.
- 財団法人 学会誌刊行センターの論文
著者
-
Kitano Takao
Department Of Public Health Graduate School Of Medical Sciences Kumamoto University
-
Futatsuka Makoto
Department Of Public Health Graduate School Of Medical Sciences Kumamoto University
-
Esashi Takatoshi
Division Of Applied Food Research National Institute Of Health And Nutrition
-
HANAI Miho
Division of Applied Food Research, National Institute of Health and Nutrition
-
KASAOKA Seiichi
Division of Applied Food Research, National Institute of Health and Nutrition
-
Hanai Miho
Division Of Applied Food Research National Institute Of Health And Nutrition:(present Address)depart
-
ESASHI Takatoshi
Division of Applied Food Research, National Institute of Health and Nutrition
-
KITANO Takao
Department of Public Health, Kumamoto University School of Medicine
関連論文
- Clinical Investigation of the Lesions Responsible for Sensory Disturbance in Minamata Disease
- Logistic Model Analysis of Neurological Findings in Minamata Disease and the Predicting Index
- Cancer Mortality in Minamata Disease Patients Exposed to Methylmercury Through Fish Diet
- Demographic Determinants for Change in Activities of Daily Living : A Cohort Study of the Elderly People in Beijing
- An Experimental Study on Changes in Finger Blood Pressure During Chain-Saw Operation
- Biological Monitoring of Styrene in FRP-Making Small Industries in Kumamoto, Japan : Winter-Summer Difference and Effect of Protective Masks in Practical Working Conditions
- In Vitro Studies on the Depigmenting Activity of 4-(p-Hydroxyphenyl)-2-Butanone
- Occupational Leukoderma in Workers Engaged in 4-(p-Hydroxyphenyl)-2-Butanone Manufacturing
- An Experimental Study on Depigmenting Activity of 4-(p-Hydroxyphenyl)-2-Butanone in C57 Black Mice
- Deficits in the Brain Growth in Rats Induced by Methylmercury Treatment during the Brain Growth Spurt
- An Evaluation of Transition in Functional States among the Elderly in Beijing, China
- The Impact of ADL Disability on Depression Symptoms in a Community of Beijing Elderly, China
- Evaluation of Body Composition Using Dual-energy X-ray Absorptiometry Skinfold Thickness and Bioelectrical Impedance Analysis in Japanese Female College Students
- Hand Arm Vibration Syndrome among Quarry Workers in Vietnam
- Mortality in a Cohort of Patients with Vibration Syndrome in Japan
- Correlation between bone mineral density and body composition in Japanese females aged 18-40 years with low forearm bone mineral density
- Correlation between Forearm Bone Mineral Density and Body Composition in Japanese Females Aged 18-40 years
- Sex differences in the effects of body mass index on blood pressure
- Serial Study on the Association between Body Mass Index and Hypertension in Rural Japanese
- Risk Estimation for Hypertension Based on Follow-up Health Examination Data in a Small Village in Kumamoto Prefecture, Japan
- An Epidemiological Study on Diabetes Mellitus in the Population Living in a Methyl Mercury Polluted Area
- Vibration Dose Disturbance Stage, and Examination Results and Subjective Symptoms in Vibration Syndrome
- Correlations among Examination Findings, Subjective Symptoms and Classification of Stages in Vibration Syndrome
- A Follow up Study on the Consequences of VWF Patients in Workers Using Chain Saws in Japanese National Forests
- Reduction of Manipulative Dexterities and Activity of Daily Living in the Patients with Vibration Induced White Finger in Japanese Forestry : Short Communication
- Autonomic Nervous Functions in Fetal Type Minamata Disease Patients : Assessment of Heart Rate Variability
- Relationship between Body Weight and Somatological Factors by Sex and Age
- Relationship between Questionnaire Survey Results of Vibration Complaints of Wheelchair Users and Vibration Transmissibility of Manual Wheelchair
- Whole-Body Vibration and Health Effectsin the Agricultural Machinery Drivers
- Vibration Exposure and Prevention in Japan
- Minamata Disease from the Viewpoint of Occupational Health
- Dose-Response Relationship for Hand-Arm Vibration Syndrome
- Transcriptional Coactivator p300/CBP-Associated Factor and p300/CBP-Associated Factor Type B Are Required for Normal Estrogen Response of the Mouse Uterus
- Association between Body Composition and Body Mass Index in Young Japanese Women
- Assessment of Vitamin D Metabolites and Combination of 1α, 25-Dihydroxyvitamin D_3 and Parathyroid Hormone on Mineralization of Embryonic Chick Femurs in Organ Culture
- 再録報文 Effect of the Protein and Oil Contents on Calcium Utilization in the Diets of Female Fischer Rats That Were Fed by Three Different Feeding Methods
- Effect of the Protein and Oil Contents on Calcium Utilization in the Diets of Female Fischer Rats That Were Fed by Three Different Feeding Methods
- Differences in the Effect of Iron-Deficient Diet on Tissue Weight, Hemoglobin Concentration and Serum Triglycerides in Fischer-344, Sprague-Dawley and Wistar Rats
- Calcium Absorption from the Ingestion of Coral-Derived Calcium by Humans
- The Interactive Effect of Dietary Protein and Vitamin Levels on the Depression of Gonadal Development in Growing Male Rats Kept under Disturbed Daily Rhythm
- The Effects of Calcium, Phosphorus, Magnesium, Sodium, and Zinc in Improving the Depression of Gonadal Development in Growing Male Rats Kept under a Disturbed Daily Rhythm : Investigations Based on the L_(2^)-Type Orthogonal Array
- Effect of Dietary Magnesium Level on Nephrocalcinosis and Growth in Rats
- Demographic Determinants for Change in Activities of Daily Living : A Cohort Study of the Elderly People in Beijing
- Bioavailability of Magnesium Contained in Roasted and Ground Soybean (Kinako) as Evaluated by Serum and Bone Magnesium Contents, Kidney Calcification, and Magnesium Absorption.
- Effect of Dietary Mineral Sources and Oil Content on Calcium Utilization and Kidney Calcification in Female Fischer Rats Fed Low-Protein Diets
- Association between Body Composition and Body Mass Index in Young Japanese Women.
- Bioavailability of Magnesium Contained in Purple Laver (Asakusa-Nori) by Rats with Scarce Magnesium, Being Evaluated from Serum Magnesium, Kidney Calcification, and Bone Magnesium Contents.