MyD88 but Not TLR2, 4 or 9 Is Essential for IL-12 Induction by Lactic Acid Bacteria
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概要
- 論文の詳細を見る
Although lactic acid bacteria (LAB) affect the immune system, for example, having an anti-allergic effect, little is known about the actual mechanisms of immune modulation. Toll-like receptors (TLRs) recognize conserved microbial molecular patterns, and are presumed to be involved in the recognition of LAB. However, there are few detailed reports examining the relationships between TLR and LAB. We measured here production of IL-12, a cytokine considered to play an important role in anti-allergic effects, induced by Lactobacillus paracasei strain KW3110 and other typical LAB by cells from TLR2-, TLR4-, TLR9- and myeloid differentiation factor 88 (MyD88)-deficient mice. Unexpectedly, similar cytokine production from wild-type and TLR2-, 4- and 9-deficient mice was observed. In contrast, cells from MyD88-deficient mice failed to respond to stimulation with LAB. It is therefore concluded that although LAB, including strain KW3110, are not likely to be recognized by TLR2, 4 or 9, MyD88 is essential for the response to these bacteria.
- 社団法人 日本農芸化学会の論文
著者
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SAKAGUCHI Masahiro
Department of Veterinary Microbiology, School of Veterinary Medicine, Azabu University
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Fujiwara Daisuke
Central Laboratories For Frontier Technol. Kirin Holdings Co. Ltd.
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Konishi Yutaka
Central Laboratories For Frontier Technol. Kirin Holdings Co. Ltd.
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KAISHO Tsuneyasu
Laboratory for Host Defense, RIKEN Research Center for Allergy and Immunology
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ICHIKAWA Shintaro
Central Laboratories for Frontier Technology, Kirin Holdings Company Ltd.
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FUJII Rei
Central Laboratories for Frontier Technology, Kirin Holdings Company Ltd.
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KOMIYAMA Yutaka
Central Laboratories for Frontier Technology, Kirin Holdings Company Ltd.
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