水中レーザーアブレーション法による生体親和性ナノ粒子の創成

概要

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Hydroxyapatite (HAp) is a bioactive and biocompatible material. Formation of HAp nanoparticles will be useful for biomedical applications. We tried to form the HAp nanoparticles by laser ablation in water using KrF excimer laser and Ti:Sapphire (Ti:S) laser. While the ablation, the density of the dispersed particles was estimated by the degradation of transmitted probe laser power through the solution. The transmitted power was degraded during the ablation, which showed the increment of the dispersed particles density. After stopping the ablation, the suspension was left for 12 hours. Then the transmitted power was smaller than 100 percent of initial value by KrF excimer laser ablation at the fluence of 11 J/cm2 and Ti:S laser ablation at every fluence. It meant that the particles were still dispersed in water. After the ablation, some amount of the solution was obtained and fell in drops on the polished titanium plate. The plates were let dry naturally for a day and then examined the particles by the scanning electron microscope. The formed particles by Ti:S laser ablation had higher content percentage of particles with sub-micron size than those by KrF excimer laser ablation. We could successfully form the HAp sub-micron particles and found that Ti:S laser ablation was more suitable for formation of sub-micron particles.
2010-09-30