尿路逆行性感染に対するDKBの使用経験

概要

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DKB is an antibiotic of aminoglucoside group and a kanamycin derivative having chemical structure of 3', 4'-dideoxy-kanamycin B. DKB was administered to the patients with intractable urinary tract infection due to postoperative inlying catheters. 1) MIC for each isolated organism was as follows. Pseudomonas aeruginosa 1.56～100 mcg/ml E. coli 1.56～12.5 Proteus vulgaris 3.13　mirabilis 0.78 50 Klebsiella 3.13 Citrobacter 6.25 Enterobacter 1. 56～>100 Enterococcus 6.25～>100 Candida >100 2) The highest blood level after intramuscular administration of 50 mg DKB was observed at 30 minutes in two subjects with normal renal function. The blood level decreased to 1.33 mcg /ml and 2.25 mcg/ml at six hours respectively. The highest urinary level was observed one to two hours after injection. Six hours urinary recovery of the antibiotic was 60.3 % and 80.0 %. 3) Clinical evaluation was made on 16 patients. Effectiveness rate was 68.7 %, and if limited with post-prostatectomy cases it was 66.6 %. 4) No side reaction was observed regarding hematological, renal function, liver function examinations as far as five days administration of 100 mg per day. Tinnitus and skin rash was experienced in a case respectively.