[原著］再発悪性グリオ-マに対するIFN-β局所投与とACNU動注療法の試み

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Five cases of recurrent malignant gliomas were treated with local injection of interferon- βcombined with intracarotid injection of 1-(4-amino 2methy1-5-pyrimidinyl)methy1 -3-(2-chlor∝thy1)-3-nitrosourea hydrochloride(ACNU). All patients had been already treated with intravenous injection of IFN-β and/or ACNU as well as conventional radiotherapy after surgery. IFN-β(3×10^6 IU, 3 times a week) was locally injected through a catheter placed into tumor-removed cavity. ACNU (100mg/6weeks) was injected into the carotid artery following osmotic blood brain barrier modification produced by arterial injetion of 20% 200ml mannitol. Multiple intracranial lesions were checked with contrast enhanced CT in all cases. None of the cases exhibited clinical regression. But three of them showed tumor regression around the IFN-β injected cavity, although the other part of the tumor remained progressive. These results suggested that direct tumorddal effects of IFN-β was exhibited to recurrent malignant gliomas, and local injection of IFN-β is so useful that should be used from the initial stage in addition to its intravenous use. There should be some strategic ideas to overcome ACNU resistance when reused.
琉球大学医学部,Faculty of Medicine, University of the Ryukyusの論文