尿路結石関連物質の日内変動の検討

概要

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健康男子5人について各食餌の摂取時間を一定とし,尿量,尿pH,クレアチニン,カルシウム,マグネシウム,リン,尿酸,クエン酸および蓚酸の日内変動を2時間ごと(深夜は6時間尿)の採尿で検討し,尿pHに二峰性の日内変動のあること,尿量は深夜に減少すること,クレアチニンの排泄量の日内変動が僅かであったこと,リンを除く他の物質は夜間から早朝にかけて排泄量の減少がみられ,各食餌摂取後に増加傾向,とくに夕食後に著明に増加することなどを認めたThe diurnal variations of urine composition with respect to urinary pH, volume, creatinine, calcium, magnesium, phosphate, uric acid, citrate and oxalate were studied in five healthy men. Generally, there was considerable variations in the excretion of the different urine constituents with meal related peaks except phosphate, which was most pronounced after dinner. The analysis of a 24-hour urine collection cannot account fully for the crystallization properties of urine and a fractionated urinalysis might be of value for therapeutic decisions. However, such procedures probably will not be possible in clinical practice and more reliable methods for evaluation of the crystallization propensity in whole 24-hour urine have to be developed.