硫酸アミカシンの局所投与の検討

概要

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1)膀胱内カテーテル留置32例と腎盂内カテーテル留置12例,計44例に対しAMKを局所投与した.臨床成績では著効3例,有効24例,やや有効11例,無効6例で有効率は61.4%であった.2)細菌学的効果では,単数菌感染16例の有効率は68.8%で,複数菌感染28例では57.1%であった.3)局所投与のAMKの血中への移行はきわめて少なかった.4)全例で,あきらかな副作用は認めなかったAmikacin sulfate (AMK) was used against urinary tract infections (UTI) as local administration such as bladder lavage, renal pelvic lavage and vesical instillation. Forty four patients with UTI were treated by this method, 32 patients having Foley catheter indwelling in the bladder and 12 patients having drainage catheter indwelling in the renal pelvis. The overall clinical effect under UTI judgment was 3 excellent cases, 24 good, 11 fair and 6 poor, with an efficiency of 61.4%. A total of 100 bacteria, 47 gram positive, 33 gram negative, 6 anaerobes and 14 fungi, were found in the urine and bacteriological effect was 68.8% and 57.1% in single and combined bacterial infection, respectively. The serum concentration of AMK was measured in 9 patients by radioimmunoassay, and the maximum concentration was 0.38 micrograms/ml which is a low absorption rate. There were no adverse reactions during or after treatment with AMK.