淋菌性尿道炎に対するpipemidic acidの臨床効果について

概要

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淋菌性尿道炎症例20例についてPipemidic acid (PPA)を投与した.1) PPAの臨床効果ならびに有用性についてみると,著効9例,有効6例で,有効率は20例中15例(75%)であった.2)分離培養しえた14株についてMICを測定した結果,1.56 μg/ml (0.78～3.13 μg/ml)であった.なお,14株中1株にβ-lactamase産生株を認めたが,これに対するPPAの臨床効果は有効であったTwenty cases of gonorrhoeal urethritis were orally treated with pipemidic acid (PPA). The results are as follows. The clinical effect of PPA was excellent in 9 cases and good in 6 cases, the efficacy rate being 75%. The usefulness of PPA was satisfactory in 12 cases (60%). No side effects were observed. The minimal inhibitory concentrations against 14 isolated Neisseria gonorrhoeal strains ranged from 0.78 to 3.13 micrograms/ml with a median value of 1.56 micrograms/ml. A beta-lactamase-producing strain was observed among the 14 strains and the case infected by this strain was successfully treated with PPA. These results indicate that PPA is a useful drug for the treatment of gonorrhoeal urethritis.