Focal fractionated radiotherapy for intramedullary spinal arteriovenous malformations: 10-year experience.
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概要
- 論文の詳細を見る
Object. Radiosurgical treatment of spinal arteriovenous malformations (AVMs) is becoming a practical therapeuticoption as methodology improves, but no comparative study has yet been published on focal fractionated radiotherapy. Theauthors report their experience with conventional and hypofractionated radiotherapy for spinal AVM.Methods. Candidates for this study were patients who experienced symptoms due to an intramedullary AVM but wereineligible for embolization or surgery. Of 21 patients with spinal AVMs, 10 cases in a 10-year period met this criterion.Angiography and contrast-enhanced computerized tomography scanning were used for treatment planning in all cases.Fractionated radiotherapy was performed using a linear accelerator, extracranial immobilization system, and frequentorthogonal linacographic verification. The starting radiation dose was 32 Gy in two, 36 Gy in three, and 40 Gy in twopatients, in a regimen involving 1.8 to 2–Gy daily fractions; this was recently changed to a hypofractionation schedule of30 Gy (in eight sessions) in one and 20 Gy (in four sessions) in two patients.Results. The follow-up period ranged from 26 to 124 months (median of 49 months). There were no hemorrhages norany adverse reactions attributable to irradiation. Of the seven patients who consented to undergo follow-up angiography,the nidus size decreased in five, but complete obliteration did not occur in any patient.Conclusions. Because no patient experienced adverse effects, the maximum tolerable radiation dose for the spinal cordassociated with an AVM could not be identified, although it presumably is higher than those administered. The lack ofrebleeding in patients in whom complete angiographic occlusion was absent suggests that the natural history of spinalAVMs may be less aggressive than previously reported.
- American Association of Neurological Surgeonsの論文
著者
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飛騨 一利
北海道大学医学部神経外科
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Shirato Hiroki
Department Of Radiology Hokkaido University Graduate School Of Medicine
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AOYAMA Hidefumi
Department of Radiology, Hokkaido University Graduate School of Medicine
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Iwasaki Y
Miyagi National Hospital
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Seki Toshitaka
Department Of Neurosurgery Graduate School Of Medicine University Of Hokkaido
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Aoyama Hidefumi
Department Of Radiology Hokkaido University Graduate School Of Medicine
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IWASAKI Yoshinobu
Sapporo Azabu Neurosurgical Hospital
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Iwasaki Yoshinobu
Department Of Neurosurgery Sapporo Azabu Neurosurgical Hospital
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