The Effect of Hepatocyte Growth Factor (HGF) on Promotion of Endothelial Healing of Balloon-injured Carotid Artery

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概要

• 論文の詳細を見る

• Purpose: This animal study was designed to examine the effect of hepatocyte grouth factor on suppression of intimal hyperplasia resulting from reendothelialization after balloon injury in the rat carotid artery. Methods: Fourteen Sprague-Dawely rats were subjected to balloon injury; treatment groups in which 0.1mg/body HGF (0.1mg HGF group; n=5) or 0.2mg/body HGF (0.2-mg HGF group; n=3) was infused in the same way. Rats were killed 14 days after surgery, and the carotid artery was harvested. Results: Intima/media (I/M) ratio was 0.98±0.15 in the control group, 0.73±0.17 in the 0.1-mg HGF group and 0.65±0.05 in the 0.2-mg HGF group. Reendothelialization extended 3.4±0.74 mm in the control group, 5.5±0.5 mm in the 0.1-mg HGF group and 5.6±2.1 mm in the 0.2-mg HGF group at the proximal site. These were no significant differences between groups in I/M ratio or reendothelialization. Conclusion: HGF is not effective on intimal healing in this model in terms of endothelial cell ingrowth and suppression of intimal thickening.

• Yamaguchi University Graduate School of Medicineの論文

著者

• Hiro Takafumi

  Division Of Cardiology Department Of Medicine Nihon University School Of Medicine

• Zempo Nobuya

  First Department Of Surgery Yamaguchi University School Of Medicine

• Esato K

  Department Of Surgery Yamaguchi University School Of Medicine

• Esato Kensuke

  First Department Of Surgery.yamaguchi University School Of Medicine

• Hayashi Masatarou

  First Department Of Surgery Yamaguchi University School Of Medicine

• Zempo Nobuya

  Department Of Surgery I Yamaguchi University School Of Medicine

• Zempo Nobuya

  First Department Of Surgery Yamaguchi University School Of Medicine.

• Esato Kensuke

  First Department Of Surgery Yamaguchi University School Of Medicine.

• NAGANO TOMOKAZU

  Discovery Research Laboratories, Sumitomo Pharmaceuticals Research Center

• TAIJI MUTSUO

  Discovery Research Laboratories, Sumitomo Pharmaceuticals Research Center

• NOGUCHI HIROSHI

  Discovery Research Laboratories, Sumitomo Pharmaceuticals Research Center

• Hisaoka Takayuki

  Second Department Of Internal Medicine Yamaguchi University School Of Medicine

• Harada Masakazu

  山口大学 第1外科

• Zenpo Nobuya

  First Department Of Surgery Yamaguchi University School Of Medicine

• Noguchi H

  Faculty Of Eng. Dept. Of Design & Architecture Chiba University

• Harada Masakazu

  First Department Of Surgery Yamaguchi University School Of Medicine

• Hayashi Masataro

  Department Of Surgery And Clinical Science Yamaguchi University Graduate School Of Medicine

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