NUCLEAR p53 OVEREXPRESSION ＩＮ PATHOLOGICAL T1BLADDER CANCER: A MARKER FOR TUMOR RECURRENCE AND TUMOR PROGRESSION

概要

論文の詳細を見る
In order to investigate the malignant potential of stage T1 bladdar tumors the status of p53 overexpression and mucosal change of grossly normal bladder mucosa, respectively, were studied regarding tumor recurrence and tumor progresion. A total of 30 cases with stage T1 bladder tumor were enrolled and selected site mucosal biopsies (SSMB) were taken of randomly selected 17 cases. All cases were treated by transurethral resection and followed for a median period of 39 months. Six of the 30 cases (20%) showed p53 overexpression. Five of the 17 (29%) had mucosal changes (carcinoma in situ;1, dysplasia;4). Out of 6 cases with p53 overexpression, 3 (50%) showed tumor progression, in contrast to only 2 (8%) of 24 cases without p53 overexpession (p＜0.05, fisher's test). Statistically significant differences were found in recurrence-free and progression-free survival between patients whose tumor had p53 overexpression and those whose tumor did not (both p＜0.01, Log Rank test). Signficant correlations were not found between mucosal change of grossly normal bladder mucosa and tumor recurrence, or progressin. These results suggest that p53 overexpression in the main tumor might be of useful prognostic marker for recurrence as well as tumor progression.
Yamaguchi University Graduate School of Medicineの論文