J024042 薬液粒子の鼻腔内沈着特性に関する研究([J02404]バイオにおける流れと熱・物質移動(4))

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Nebulizer treatment has been used for nasal diseases such as paranasal sinusitis, hypertrophic rhinitis and inferior concha inflammation. The effectiveness of the nebulizer treatment has been confirmed from clinical view points until now. However there are a few researches that evaluate the effect of the nebulizer treatment quantitatively, i.e., how medicinal mist transports and deposits on inflammation areas of nasal wall. Some researchers calculated intranasal transport phenomena of medicinal droplets using Computed Fluid Dynamics (CFD). However these researches analyzed a few cases. The individual difference was left out of consideration even though there were different shapes of nasal cavities and different grade of medical conditions. This study constructs three-dimensional geometry model of nasal cavity using an actual patient's CT data. The case undergoes deviated nasal septum, hypertrophic rhinitis, chronic sinusitis and bloating inferior nasal concha tumentia. This study analyzes the characteristics of airflow and medicinal droplet, especially focuses on local deposition characteristics. As a result airflow velocity and pressure drop increase in the narrowing region caused by jet effect. Inlet angle and velocity of nebulizer treatment can easily control medicinal droplet transport characteristics. The circulatory flow is able to contribute advances medicinal droplet transportation in widespread area of intranasal.
一般社団法人日本機械学会の論文
2011-09-11

J024042 薬液粒子の鼻腔内沈着特性に関する研究([J02404]バイオにおける流れと熱・物質移動(4))

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