歯科口腔外科領域における自己多血小板血漿ゲルの応用(再生医療とアフェレシス)

概要

論文の詳細を見る
Predeposit autologous blood can be separated into red blood cells(containing MAP as preservative solution)and autologous FFP by centrifugation. The layer of buffy coat is secondar- ily centrifuged and autologous platelet-rich plasma(PRP)can be separated. PRP is mixed with calcium gluconate and thrombin, and then used as a PRP gel. PRP gel is mixed with particulate cancellous bone and marrow and transplanted into the defects for remodeling the bone in the field of oral surgery. Among 81 cases of predeposit autologous blood transfusion in the oral surgery division, autologous PRP gel was prepared and used in 21 cases with maxillary defects due to cleft palate or mandibular defects due to malignant tumor extirpations. The average concentration ratio of platelets was 5.5±1.3times of the peripheral blood. No case with failure or infection of the bone graft was observed. Jaw bones were well reconstructed in the 21 cases. Autologous PRP gel is easily created and safe because it is derived autologous blood, and clinically effective for remodeling bone. In the future, it is presumed that PRP gel will be applied to other fields where bone formation is required.
日本アフェレシス学会の論文
2006-10-31