OS0908 銅ナノワイヤの創製および幹細胞成長への応用(OS9-2 生体機能・材料(細胞),OS-9 生体機能・材料)

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Many studies have focused on the fabrication of copper nanowires, because of their potential applications such as gene delivery. We successfully fabricated copper nanowires by electrochemical deposition method. Cu nanowires was synthesized by electroplating from a 0.4M CuSO_4 bath, the current was 0.005A.The length of nanowires can be controlled via deposition time and current. The length and the diameter of the nanowires are approximately 10 μm and 200nm respectively after depositing for 60 minutes. Nanowires with concentration of 10^2, 10^3, 10^4, and 10^5 were added to 96-well cell culture plate in which mesenchymal stem cells were pre-seeded. After incubating for 2 days, cytotoxicity of nanowires was measured with MIT assay method. Results indicated that cytotoxicity increased as the increase of nanowires density. Cell viability is approximately 80 % at the density of 10^5 compared with the control group, and at a lower density (10^2), mesenchymal stem cells were almost unaffected.
2011-07-16