217205 誘電泳動力による細胞の位置制御(OS07 細胞・生体組織2,オーガナイズド・セッション)

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When an AC electric field is applied to a particle, a dielectrophoretic (DEP) force arises. If that field is inhomogeneous, then the particles experience a DEP force, the frequency response of which is a function of their intrinsic electrical properties. In the present study, the DEP forces exerted between cultured HeLa cells exposed to an AC electric field of 20kV/m with the frequency of 1kHz were utilized to control positions of the corresponding cells suspended in culture media. A uniform AC electric field was applied to induce the DEP force between cells, whose magnitude and direction have strong dependencies on cell's spatial configuration. Results show that the force strength is highly frequency sensitive, and cells aggregate in response to the field distribution that varies with varying formation of cluster of cells. Numerical simulations based on the Langevin equation of particle dynamics were also performed and predicted behaviors of cells.
一般社団法人日本機械学会の論文
2011-03-17