ビオチンの栄養評価法に関する最近の進歩(若手シンポジウム「ビタミン基礎研究の進展を担う若手研究者たち」,<特集>ビタミン基礎研究の進展を担う若手研究者たち(第64回大会若手シンポジウム))

概要

論文の詳細を見る
Biotin serves as a covalently bound coenzyme for various carboxylases in mammals. Deficiency of this vitamin leads to a variety of clinical abnormalities that include neurological disorders and dermatological abnormalities. It has been thought that human biotin deficiency is extremely rare since biotin is present in various foods. However, it has been reported that marginal biotin deficiency develops during normal human gestation and that biotin deficiency is teratogenic in several animal species. It has also been reported that the possibility of biotin deficiency is increased in infants who were fed a special formula for the treatment of allergies. These findings indicate that it is still needed to evaluate the biotin status of human subjects. This review provides the recent advances in methods for the assessment of the biotin status.
2013-01-25