Gelatin sponge sheet combined with gelatin glue as new topical hemostatic materials : a preliminary report in an animal model
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概要
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Hemostasis is a key issue in surgery because uncontrolled surgical bleeding is associated with increased mortality rates and higher costs. Many types of topical hemostatic materials have been developed. One of the most current and most effective materials is TachoComb (TC), which is reabsorbed well by conversion into connective tissue. However, TC's excellent hemostatic effects are brought about by the use of hemostatic components and a framework derived from human and animal tissues. This means that TC use is associated with a risk of infectious diseases and allergic reactions. To address the above-mentioned problems with the most current hemostatic material, we devised a new hemostatic material composed of a framework of a freeze-dried gelatin sponge combined with gelatin glue, thereby creating a new topical hemostatic material made of gelatin alone. The gelatin used in the material was prepared with alkali-treatment, and the immunogenicity and activity of viruses were eliminated almost completely. The framework absorbs blood flowing out from the wound immediately, activates autologous coagulation components in the absorbed blood and promotes blood coagulation at the bleeding site. The hemostatic effects of three types of hemostatic materials were compared, namely (A) the gelatin sponge combined with gelatin glue, (B) TC and (C) gelatin glue alone, using a dog's spleen with a shaved wound surface. Consequently, combined use of the gelatin sponge and gelatin glue exhibited significantly superior hemostatic effects to the other two materials. In the conclusion, the combination of a gelatin sponge sheet and gelatin glue is useful as a topical hemostatic material due to its superior hemostatic effects and extremely low risk of infectious diseases and allergic reactions.
- 2013-04-00
著者
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Tsujimoto Hiroyuki
Department Of Biotechnology Faculty Of Engineering Kansai University
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Hagiwara Akeo
Department Of Digestive Surgery Kyoto Prefectural University Of Medicine
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Ikeda Junki
Department of Medical Life System, Doshisha University
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Orikasa Taichi
Department of Medical Life System, Doshisha University
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Kotani Yutaka
Undergraduate Senior, Department of Medical Life System, Doshisha University
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Wang Zhen
Undergraduate Senior, Department of Medical Life System, Doshisha University
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Kawasumi Akari
Undergraduate Senior, Department of Medical Life System, Doshisha University
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Tamura Atsushi
Undergraduate Senior, Department of Medical Life System, Doshisha University
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Tsuji Misaki
Undergraduate Senior, Department of Medical Life System, Doshisha University
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Hayashi Maho
Undergraduate Senior, Department of Medical Life System, Doshisha University
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Torii Hiroko
Department of Medical Life System, Doshisha University/Department of Kusatsu General Hospital
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Morita Shinichiro
Research and Development Department, Gunze Ltd
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Torii Hiroko
Department of Medical Life System, Doshisha University/Kusatsu General Hospital
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Takamori Hideki
Research and Development Department, Gunze Ltd
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Ozamoto Yuki
Kusatsu General Hospital
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