Chitosan sponge has a better local hemostatic effect than alginate sponge in animal experiment

概要

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Collagen-preparation and fibrin glue are widely used local hemostatic materials. Collagen-preparation, however, can promote local infections, and tends to cause allergic reactions, since it contains proteins from different kinds of animals. Fibrin glue is associated with risks of viral infections, because it contains materials from human beings. Therefore, this laboratory developed the "chitosan sponge", as a novel local hemostatic material with few such problems, because chitosan is derived from neither different kinds of animals nor humans but from crabs. In the experiment, chitosan sponge was made by a freeze-drying method, and was evaluated in for tissue-adhesion intensity and hemostatic effects, in comparison to sponge of alginate, another hemostatic material. The tissue-adhesion intensity of these materials was evaluated by their maximal shear stress. The maximal shear stress in the chitosan group was significantly large in comparison to that in the alginate group. The hemostatic effect was indicated with blood amount bleeding from the mesentery in rats. There was significantly little bleeding in the chitosan group in comparison to that in the alginate group. These results suggest that the chitosan sponge can be useful as a novel local hemostatic material.