The Molecule Mechanism and Development of a Cure of the Muscle Atrophy by Unloading

概要

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Under weightlessness or bedridden environment (unloading), skeletal muscle shrinks remarkably and shows the rapid aging of a locomotorium. Then, we are solving the molecule mechanism of muscle atrophy, and aim at contributing to development of the cure. METHODS: We used Space Fright or Teil Suspension mice, and examined the influence of muscle atrophy. RESULTS: We discovered that expression of Cbl-b (Casitus B-ligeage lymphoma-b) was increasing of the space flight mice. Cbl-b ubiquitin ligase interacts with and degraded IGF-1 signaling intermediate IRS-1. Furthermore, in a Cbl-b KO mice, the muscle atrophy by unloading slight happened. CONCLUSIONS: This study suggested that Cbl-b ubiqutin ligase adjusted the growth factor receptor signal system of muscle cells to negative, and it is one of the important genes which cause atrophy of a locomotorium. This molecule is targeted, we development the nutrient material which can inhibit IGF-1 degradation. As a future target, we would like to show clearly how skeletal muscle detects Unloading stress by clarifying the regulation of expression mechanism of Cbl-b.