Regulation of skeletal muscle atrophy
スポンサーリンク
概要
- 論文の詳細を見る
Skeletal muscle atrophy can result from prolonged periods of skeletal muscle inactivity due to bed rest, denervation, or unloading. Such unloading-associated atrophy of skeletal muscle is characterized by both an increase in protein degradation and a decrease in protein synthesis. Successful treatments for skeletal muscle atrophy could either block protein degradation pathways activated during atrophy, or stimulate protein synthesis pathways induced during skeletal muscle hypertrophy. In this review, we mainly focus on the Insulin-like growth factor 1 (IGF-1)/Insulin receptor substrate 1 (IRS-1) pathway in muscle, because there is increasing evidence indicating that inhibition of this pathway in muscle is involved in the progression of disuse atrophy. We also focus on the signaling pathways that control skeletal muscle atrophy, including muscle atrophy-associated ubiqitin ligases such as Cbl-b, muscle RING finger 1 (MuRF1), and muscle atrophy F-box (MAFbx)/atrogin-1.
- The Japanese Society of Physical Fitness and Sports Medicineの論文
著者
-
Nikawa Takeshi
Department Of Nutrition School Of Medicine The University Of Tokushima
-
Nikawa Takeshi
Department of Nutritional Physiology, Institute of Health Biosciences, The University of Tokushima Graduate School
-
Teshima-Kondo Shigetada
Department of Nutritional Physiology, Institute of Health Biosciences, The University of Tokushima Graduate School
関連論文
- "Myo Lab" : A JAXA Cell Biology Experiment in "Kibo (JEM)" of the International Space Station
- Effects of Dimethyl Sulphoxide and Dexamethasone on mRNA Expression of Myogenesis- and Muscle Proteolytic System-related Genes in Mouse Myoblastic C2C12 Cells
- Distinct gene expression profiles in the femora of rats exposed to spaceflight, tail-suspension and denervation
- Preventive Effect of Isometric Contraction Exercise on Disuse Muscle Atrophy Using Tail Suspension Mice
- A Relative High Dose of Vitamin E Does Not Attenuate Unweighting-Induced Oxidative Stress and Ubiquitination in Rat Skeletal Muscle
- A Cysteine Protease Inhibitor Prevents Suspension-Induced Declines in Bone Weight and Strength in Rats
- Cathepsin C Propeptide Interacts with Intestinal Alkaline Phosphatase and Heat Shock Cognate Protein 70 in Human Caco-2 Cells
- A Skeletal Muscle-Derived Secretory Protein, Attractin, Upregulates UCP-2 Expression in Mouse 3T3-L1 Adipocytes
- Short-term hypergravity does not affect protein-ubiquitination and proliferation in rat L6 myoblastic cells
- Glutathione depletion inhibits oxidant-induced activation of nuclear factor-kappa B, AP-1, and c-Jun/ATF-2 in cultured guinea-pig gastric epithelial cells
- Interleukin 10 inhibits interferon γ- and tumor necrosis factor α-stimulated activation of NADPH oxidase 1 in human colonic epithelial cells and the mouse colon
- “Hybrid Exercise” Prevents Muscle Atrophy in Association with a Distinct Gene Expression Pattern
- Effects of a High-Protein Diet on Host Resistance to Paracoccidioides brasiliensis in Mice
- Effect of Dietary Oils on Host Resistance to Fungal Infection in Psychologically Stressed Mice
- Effect of Dietary Oils on Lymphocyte Immunological Activity in Psychologically Stressed Mice
- The Molecule Mechanism and Development of a Cure of the Muscle Atrophy by Unloading
- Alteration of the Respiratory Burst and Phagocytosis of Macrophages under Protein Malnutrition
- Regulation of skeletal muscle atrophy
- Amino Acids and Glucose Differentially Increased Extracellular 5-Hydroxyindoleacetic Acid in the Rat Brain.
- S.L. Molecular mechanisms of unloading-mediated muscle atrophy and development of its countermeasures(The Proceedings of the 19th Annual Meetings of Japan Society of Exercise and Sports Physiology August 25・26, (Tokushima))
- An Intracellular Fragment of Osteoactivin Formed by Ectodomain Shedding Translocated to the Nucleoplasm and Bound to RNA Binding Proteins